[HTML][HTML] Animal models of atherosclerosis

BE Veseli, P Perrotta, GRA De Meyer, L Roth… - European journal of …, 2017 - Elsevier
An ideal animal model of atherosclerosis resembles human anatomy and pathophysiology
and has the potential to be used in medical and pharmaceutical research to obtain results …

Vein graft failure: from pathophysiology to clinical outcomes

MR De Vries, KH Simons, JW Jukema… - Nature Reviews …, 2016 - nature.com
Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside
from balloon angioplasty, bypass graft surgery is the most commonly performed …

Inflammation induces endothelial‐to‐mesenchymal transition and promotes vascular calcification through downregulation of BMPR2

G Sánchez‐Duffhues… - The Journal of …, 2019 - Wiley Online Library
Endothelial‐to‐mesenchymal transition (EndMT) has been unveiled as a common cause for
a multitude of human pathologies, including cancer and cardiovascular disease. Vascular …

Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture

AC Newby - Physiological reviews, 2005 - journals.physiology.org
Intimal thickening, the accumulation of cells and extracellular matrix within the inner vessel
wall, is a physiological response to mechanical injury, increased wall stress, or chemical …

Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice

Y Hu, Z Zhang, E Torsney, AR Afzal… - The Journal of …, 2004 - Am Soc Clin Investig
Recent evidence indicates that vascular progenitor cells may be the source of smooth
muscle cells (SMCs) that accumulate in atherosclerotic lesions, but the origin of these …

Molecular mechanisms in intimal hyperplasia

AC Newby, AB Zaltsman - The Journal of pathology, 2000 - Wiley Online Library
Intimal hyperplasia is the process by which the cell population increases within the
innermost layer of the arterial wall, such as occurs physiologically during closure of the …

Endothelial mechanotransduction, redox signaling and the regulation of vascular inflammatory pathways

S Chatterjee - Frontiers in physiology, 2018 - frontiersin.org
The endothelium that lines the interior of blood vessels is directly exposed to blood flow. The
shear stress arising from blood flow is “sensed” by the endothelium and is “transduced” into …

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

HJ Chun, ZA Ali, Y Kojima, RK Kundu… - The Journal of …, 2008 - Am Soc Clin Investig
Apelin and its cognate G protein–coupled receptor APJ constitute a signaling pathway with a
positive inotropic effect on cardiac function and a vasodepressor function in the systemic …

Most important chronic complications of arteriovenous fistulas for hemodialysis

R Stolic - Medical principles and practice, 2013 - karger.com
The aim of this review was to highlight the most important complications of arteriovenous
fistulas (AVFs) for hemodialysis (HD). The quality of vascular access for HD should be …

The effect of pressure-induced mechanical stretch on vascular wall differential gene expression

MA Anwar, J Shalhoub, CS Lim, MS Gohel… - Journal of vascular …, 2012 - karger.com
High blood pressure is responsible for the modulation of blood vessel morphology and
function. Arterial hypertension is considered to play a significant role in atherosclerotic …