The vinca alkaloids have been used in the treatment of cancer for over 40 years. Their
efficacy has ensured that they remain among the drugs of choice for a number of human …

Taxol®(paclitaxel) and Taxotère®(docetaxel) are currently considered to be among the most
important anticancer drugs in cancer chemotherapy. The anticancer activity of these drugs is …

BMS-247550, a novel epothilone derivative, is being developed by Bristol-Myers Squibb
Company (BMS) as an anticancer agent for the treatment of patients with malignant tumors …

The lactone-bearing polyhydroxylated alkatetraene (+)-discodermolide, which was isolated
from the sponge Discodermia dissoluta, induces the polymerization of purified tubulin with …

Taxol (paclitaxel), a complex diterpene obtained from the Pacific yew, Taxus brevifolia, is
arguably the most important new drug in cancer chemotherapy. The mechanism of cytotoxic …

Paclitaxel and docetaxel are among the most widely used chemotherapeutic drugs against
various types of cancer. However, these drugs cause undesirable side effects as well as …

Small‐molecule natural products are presumably often biosynthesized with a view to
optimizing their ability to bind to strategic proteins or other biomolecular targets. Although …

A concise modular laboratory construction of the epothilone class of promising antitumor
agents has been accomplished. For the first time in the epothilone area, the new synthesis …

We provide a full account of the discovery of the (E)-9, 10-dehydro derivatives of 12, 13-
desoxyepothilone B (dEpoB), a new class of antitumor agents with promising in vivo …

The epothilone natural products [1] exhibit extraordinary cytotoxic biological activity by
promoting GTP-independent tubulin polymerization. This mode of action inhibits the growth …