An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

The molecular mechanisms underlying SARS-CoV-2 host cell invasion and life cycle have
been studied extensively in recent years, with a primary focus on viral entry and …

All coronaviruses (CoVs) encode for a conserved macrodomain (Mac1) located in non-
structural protein 3. Mac1 is an ADP-ribosylhydrolase that binds and hydrolyzes mono-ADP …

The severe acute respiratory syndrome coronavirus 2 pandemic is characterized by the
emergence of novel variants of concern (VOCs) that replace ancestral strains. Here, we …

A strategy for pandemic preparedness is the development of antivirals against a wide set of
viral targets with complementary mechanisms of action. SARS-CoV-2 nsp3-mac1 is a viral …

SARS-CoV-2 continues to pose a threat to public health. Current therapeutics remain limited
to direct acting antivirals that lack distinct mechanisms of action and are already showing …

All coronaviruses (CoVs) encode for a conserved macrodomain (Mac1) located in
nonstructural protein 3 (nsp3). Mac1 is an ADP-ribosylhydrolase that binds and hydrolyzes …

Viral macrodomains that can bind to or hydrolyze protein adenosine diphosphate
ribosylation (ADP-ribosylation) have emerged as promising targets for antiviral drug …

The COVID-19 pandemic has highlighted the lack of effective, ready-to-use antivirals for the
treatment of viruses with pandemic potential. The development of a diverse drug portfolio is …

Coronaviruses (CoVs) can emerge from zoonotic sources and cause severe diseases in
humans and animals. All CoVs encode for a macrodomain (Mac1) that binds to and removes …