Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

A wide variety of laboratory apparatuses have been devised for mechanical stimulation of
cell and tissue cultures. This article reviews the functional attributes of several dozen …

Throughout their lives, all cells constantly experience and respond to various mechanical
forces. These frequently originate externally but can also arise internally as a result of the …

Abstract Munc13-1, a mammalian homolog of C. elegans unc-13p, is thought to be involved
in the regulation of synaptic transmission. We now demonstrate that Munc13-1 is a …

Recent advances in microfluidics have brought forth new tools for studying flow-induced
effects on mammalian cells, with important applications in cardiovascular, bone and cancer …

In the circulation, flow-responsive endothelial cells (ECs) lining the lumen of blood vessels
are continuously exposed to complex hemodynamic forces. To increase our understanding …

Ebola virus causes severe hemorrhagic fever with high mortality rates in humans and
nonhuman primates. Vascular instability and dysregulation are disease-decisive symptoms …