Antioxidant and oxidative stress: a mutual interplay in age-related diseases

BL Tan, ME Norhaizan, WPP Liew… - Frontiers in …, 2018 - frontiersin.org
Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol

HY Peh, WSD Tan, W Liao, WSF Wong - Pharmacology & therapeutics, 2016 - Elsevier
The discovery of vitamin E (α-tocopherol) began in 1922 as a vital component required in
reproduction. Today, there are eight naturally occurring vitamin E isoforms, namely α-, β-, γ …

Role of vitamins beyond vitamin D3 in bone health and osteoporosis

AV Skalny, M Aschner, A Tsatsakis… - International …, 2023 - spandidos-publications.com
The objective of the present review was to summarize the molecular mechanisms
associated with the effects of the vitamins A, C, E and K, and group B vitamins on bone and …

Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy

K Parvaneh, M Ebrahimi, MR Sabran… - BioMed research …, 2015 - Wiley Online Library
Probiotics are live microorganisms that exert beneficial effects on the host, when
administered in adequate amounts. Mostly, probiotics affect the gastrointestinal (GI) tract of …

Quercetin and vitamin E alleviate ovariectomy‐induced osteoporosis by modulating autophagy and apoptosis in rat bone cells

S Vakili, F Zal, Z Mostafavi‐pour… - Journal of cellular …, 2021 - Wiley Online Library
Osteoporosis is the most prevalent metabolic bone disease and one of the most important
postmenopausal consequences. The aim of this study was to investigate the effects of …

Potential role of tocotrienols on non-communicable diseases: a review of current evidence

SK Wong, Y Kamisah, N Mohamed, N Muhammad… - Nutrients, 2020 - mdpi.com
Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties.
This review aimed to summarize the health benefits of T3, particularly in prevention or …

The molecular mechanism of vitamin E as a bone-protecting agent: a review on current evidence

SK Wong, NV Mohamad, NI Ibrahim, KY Chin… - International journal of …, 2019 - mdpi.com
Bone remodelling is a tightly-coordinated and lifelong process of replacing old damaged
bone with newly-synthesized healthy bone. In the bone remodelling cycle, bone resorption …

Tocopherol attenuates the oxidative stress of BMSCs by inhibiting ferroptosis through the PI3k/AKT/mTOR pathway

D Lan, C Yao, X Li, H Liu, D Wang… - … in bioengineering and …, 2022 - frontiersin.org
Oxidative stress can induce bone tissue damage and the occurrence of multiple diseases.
As a type of traditional medicine, tocopherol has been reported to have a strong antioxidant …

The relationship between nutrient patterns and bone mineral density in postmenopausal women

BL Ilesanmi-Oyelere, L Brough, J Coad, N Roy… - Nutrients, 2019 - mdpi.com
In women, the menopausal transition is characterized by acid-base imbalance, estrogen
deficiency and rapid bone loss. Research into nutritional factors that influence bone health is …

[HTML][HTML] Self-emulsified annatto tocotrienol improves bone histomorphometric parameters in a rat model of oestrogen deficiency through suppression of skeletal …

NV Mohamad, S Ima-Nirwana… - International Journal of …, 2021 - ncbi.nlm.nih.gov
Menopause is the leading cause of osteoporosis for elderly women due to imbalanced bone
remodelling in the absence of oestrogen. The ability of tocotrienol in reversing established …