[HTML][HTML] Glycogen synthase kinase-3: A potential immunotherapeutic target in tumor microenvironment
J Liang, M Yu, Y Li, L Zhao, Q Wei - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Abstract Glycogen synthase kinase-3 (GSK-3) is a protein kinase that can phosphorylate
over a hundred substrates and regulate cell differentiation, proliferation, and death …
over a hundred substrates and regulate cell differentiation, proliferation, and death …
The genomic landscape of the immune system in lung cancer: present insights and continuing investigations
M Roshan-Zamir, A Khademolhosseini… - Frontiers in …, 2024 - frontiersin.org
Lung cancer is one of the most prevalent malignancies worldwide, contributing to over a
million cancer-related deaths annually. Despite extensive research investigating the genetic …
million cancer-related deaths annually. Despite extensive research investigating the genetic …
In-silico design, pharmacophore-based screening, and molecular docking studies reveal that benzimidazole-1,2,3-triazole hybrids as novel EGFR inhibitors targeting …
Lung cancer is a complex and heterogeneous disease, which has been associated with
various molecular alterations, including the overexpression and mutations of the epidermal …
various molecular alterations, including the overexpression and mutations of the epidermal …
Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment
W Li, Q Yuan, M Li, X He, C Shen, Y Luo, Y Tai… - Frontiers in …, 2024 - frontiersin.org
Lung cancer (LC) is one of the most common cancer worldwide. Tumor-associated
macrophages (TAMs) are important component of the tumor microenvironment (TME) and …
macrophages (TAMs) are important component of the tumor microenvironment (TME) and …
High-accuracy prediction of colorectal cancer chemotherapy efficacy using machine learning applied to gene expression data
S Amniouel, MS Jafri - Frontiers in Physiology, 2024 - frontiersin.org
Introduction: FOLFOX and FOLFIRI chemotherapy are considered standard first-line
treatment options for colorectal cancer (CRC). However, the criteria for selecting the …
treatment options for colorectal cancer (CRC). However, the criteria for selecting the …
Alveolar type 2 cells marker gene SFTPC inhibits epithelial-to-mesenchymal transition by upregulating SOX7 and suppressing WNT/β-catenin pathway in non-small …
Q Zhang, N An, Y Liu, Y Zhu, W Pan, P Gu… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Introduction Surfactant Protein C gene (SFTPC) is a marker gene of alveolar type 2 cells
(AT2), which are the key structures of alveoli. Mutations or deletions in SFTPC cause …
(AT2), which are the key structures of alveoli. Mutations or deletions in SFTPC cause …
SLIT3 deficiency promotes non-small cell lung cancer progression by modulating UBE2C/WNT signaling
Z Qiu, Y Zhan, Z Chen, W Huang, J Liao, Z Chen… - Open Life …, 2024 - degruyter.com
In our prior research, it was noted that slit guidance ligand 3 (SLIT3), a member of the SLIT-
secreted protein family, may play a potential role in tumorigenesis. In addition, our prior work …
secreted protein family, may play a potential role in tumorigenesis. In addition, our prior work …