P450BM3 (CYP102A1), a fatty acid hydroxylase from Bacillus megaterium, has been
extensively studied over a period of almost forty years. The enzyme has been redesigned to …

Highlights•Cytochrome P450 enzymes catalyse oxygen insertion into a wide range of
substrates.•Mutagenesis of P450s frequently allows novel substrate recognition.•P450s …

Cytochrome P450 enzymes primarily catalyze mixed-function oxidation reactions, plus some
reductions and rearrangements of oxygenated species, eg prostaglandins. Most of these …

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

Transfers of carbene moieties to heterocycles or cyclic alkenes to obtain C (sp2)–H
alkylation or cyclopropane products are valuable transformations for synthesis of …

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

Covering: up to the end of 2006The catalytic potential of the P450s in organic
biotransformations is the subject of this review—with emphasis on the breadth of P450 redox …

The cytochromes P450 (P450s) are a broad class of heme b-containing mono-oxygenase
enzymes. The vast majority of P450s catalyse reductive scission of molecular oxygen using …

Metabolic engineering can produce a wide range of bulk and fine chemicals using
renewable resources. These approaches frequently require high levels of activity from …

The conformation of water around proteins is of paramount importance, as it determines
protein interactions. Although the average water properties around the surface of proteins …