Cancer immunotherapy offers substantive benefit to patients with various tumour types, in
some cases leading to complete tumour clearance. However, many patients do not respond …

Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

The interferons (IFNs) were originally described over 50 years ago, identified by their ability
to confer viral resistance to cells. We now know that they are much more than just anti‐viral …

Epidermal growth factor receptor (EGFR) exists in the nucleus of highly proliferative cells
where it functions as a transcription factor. Although EGFR has transactivational activity, it …

Vitiligo is an autoimmune disease of the skin that results in the destruction of melanocytes
and the clinical appearance of white spots. Disease pathogenesis depends on IFN-γ and …

Emerging evidences suggest the existence of a new mode of epidermal growth factor
receptor (EGFR) signalling pathway in which activated EGFR undergoes nuclear …

Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells
and primary tumors for decades. While localized in the nucleus, EGFR functions as a …

Aberrant expression of epidermal growth factor receptor (EGFR) is present in many human
tumors. Several reports have shown that EGFR is translocated into the nucleus during liver …

Many receptor tyrosine kinases (RTKs) can be detected in the cell nucleus, such as EGFR,
HER‐2, HER‐3, HER‐4, and fibroblast growth factor receptor. EGFR, HER‐2 and HER‐4 …

Aberrant epidermal growth factor receptor (EGFR) signaling is a major characteristic of many
human malignancies including breast cancer. Since the discovery of EGF in 1960's and its …