Using our understanding of interactions between helminth metabolism and host immunity to target worm survival

EK Reed, KA Smith - Trends in Parasitology, 2024 - cell.com
Helminths can adapt to environmental conditions in the host, utilising anaerobic processes
like fermentation and malate dismutation to produce energy from carbohydrate. Although …

Acyl-CoA binding protein regulates nutrient-dependent autophagy

P Udupa, A Kumar, R Parit, DK Ghosh - Metabolism, 2023 - Elsevier
Background Homeostasis of autophagy under normal conditions and nutrient stress is
maintained by adaptive activation of regulatory proteins. However, the protein-lipid crosstalk …

[HTML][HTML] Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy

A Giraudo, C Bolchi, M Pallavicini, R Di Santo, R Costi… - Pharmaceuticals, 2024 - mdpi.com
Plasmodium, Leishmania, and Trypanosoma parasites are responsible for infectious
diseases threatening millions of people worldwide. Despite more recent efforts devoted to …

Investigation of the mechanism of action of mefloquine and derivatives against the parasite Echinococcus multilocularis

R Memedovski, M Preza, J Müller, T Kämpfer… - International Journal for …, 2023 - Elsevier
Alveolar echinococcosis (AE) is caused by infection with the fox tapeworm E. multilocularis.
The disease affects humans, dogs, captive monkeys, and other mammals, and it is caused …

Mefloquine improves pulmonary fibrosis by inhibiting the KCNH2/Jak2/Stat3 signaling pathway in macrophages

J Zhou, X Yang, Y Liu, J Guo, Z Liu, Y Li, Y Bai… - Biomedicine & …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a life-threatening disease characterized by severe
pulmonary fibrosis, for which there is an urgent need for effective therapeutic agents …

[HTML][HTML] PLGA-PEG-COOH nanoparticles are efficient systems for delivery of mefloquine to Echinococcus multilocularis metacestodes

B Autier, A Verger, C Plaisse, C Manuel… - Experimental …, 2024 - Elsevier
Alveolar echinococcosis (AE) is a severe disease caused by the infection with the larval
stage of Echinococcus multilocularis, the metacestode. As there is no actual curative drug …

Research on Ecofriendly Synthesis of Quinolin-4(1H)-Ones Using Fe3O4@SiO2-Diol-Phen-Pd(0) Nanocomposites as a Novel and Reusable Catalyst: Catalysis in …

AM Amshawee, R Ali, MA Hussain, M Kazemi - Catalysis Letters, 2025 - Springer
Abstract Since quinolin-4 (1H)-one derivatives are very important in medicinal chemistry due
to their unique structure and diverse biological properties, the development of new methods …

Bacteria carrying mobile colistin resistance genes and their control measures, an updated review

Q Zhang - Archives of Microbiology, 2024 - Springer
The plasmid encoded mobile colistin resistance (MCRs) enzyme poses a significant
challenge to the clinical efficacy of colistin, which is frequently employed as a last resort …

Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule‐mediated pathway

M Lampinen, E Hagforsen, S Weström… - Experimental …, 2022 - Wiley Online Library
Mastocytosis is a KIT‐related myeloproliferative disease characterised by abnormal
expansion of neoplastic mast cells (MC) in the skin or virtually any other organ system. The …

Mefloquine-induced conformational shift in Cx36 N-terminal helix leading to channel closure mediated by lipid bilayer

HJ Cho, DK Chung, HH Lee - Nature Communications, 2024 - nature.com
Abstract Connexin 36 (Cx36) forms interneuronal gap junctions, establishing electrical
synapses for rapid synaptic transmission. In disease conditions, inhibiting Cx36 gap junction …