Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Membrane active antimicrobial peptides: translating mechanistic insights to design

J Li, JJ Koh, S Liu, R Lakshminarayanan… - Frontiers in …, 2017 - frontiersin.org
Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …

A dual-mechanism antibiotic kills gram-negative bacteria and avoids drug resistance

JK Martin, JP Sheehan, BP Bratton, GM Moore… - Cell, 2020 - cell.com
The rise of antibiotic resistance and declining discovery of new antibiotics has created a
global health crisis. Of particular concern, no new antibiotic classes have been approved for …

Antimicrobial peptides: challenging journey to the pharmaceutical, biomedical, and cosmeceutical use

A Mazurkiewicz-Pisarek, J Baran, T Ciach - International journal of …, 2023 - mdpi.com
Antimicrobial peptides (AMPs), or host defence peptides, are short proteins in various life
forms. Here we discuss AMPs, which may become a promising substitute or adjuvant in …

Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria

M Masi, M Réfregiers, KM Pos - Nature microbiology, 2017 - nature.com
Researchers, clinicians and governments all recognize antimicrobial resistance as a serious
and growing threat worldwide. New antimicrobials are urgently needed, especially for …

Outer membrane permeability and antibiotic resistance

AH Delcour - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2009 - Elsevier
To date most antibiotics are targeted at intracellular processes, and must be able to
penetrate the bacterial cell envelope. In particular, the outer membrane of gram-negative …

Assembly and maintenance of lipids at the bacterial outer membrane

E Lundstedt, D Kahne, N Ruiz - Chemical reviews, 2020 - ACS Publications
The outer membrane of Gram-negative bacteria is essential for their survival in harsh
environments and provides intrinsic resistance to many antibiotics. This membrane is …

Metformin restores tetracyclines susceptibility against multidrug resistant bacteria

Y Liu, Y Jia, K Yang, R Li, X Xiao, K Zhu… - Advanced …, 2020 - Wiley Online Library
Highly persistent incidence of multidrug resistant (MDR) bacterial pathogens constitutes a
global burden for public health. An alternative strategy to alleviate such a crisis is to identify …

Type V secretion systems: an overview of passenger domain functions

I Meuskens, A Saragliadis, JC Leo… - Frontiers in microbiology, 2019 - frontiersin.org
Bacteria secrete proteins for different purposes such as communication, virulence functions,
adhesion to surfaces, nutrient acquisition, or growth inhibition of competing bacteria. For …

Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria

JE Horne, DJ Brockwell, SE Radford - Journal of Biological Chemistry, 2020 - ASBMB
β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …