Developmental pharmacology—drug disposition, action, and therapy in infants and children

GL Kearns, SM Abdel-Rahman… - … England Journal of …, 2003 - Mass Medical Soc
For those using drugs to treat infants and children, the integration of developmental
pharmacology is crucial to appropriate clinical practice. Changes in metabolic capacity …

Cytochrome P450 3A: ontogeny and drug disposition

SN de Wildt, GL Kearns, JS Leeder… - Clinical …, 1999 - Springer
The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …

Thrombolysis in pediatric stroke study

MJ Rivkin, G deVeber, RN Ichord, A Kirton, AK Chan… - Stroke, 2015 - Am Heart Assoc
Methods The TIPS study was an international multicenter, dose-adaptive, phase 1 cohort
study. Study design spanned several years with input from members of the International …

Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations

IH Bartelink, CMA Rademaker, AFAM Schobben… - Clinical …, 2006 - Springer
The approach to paediatric drug dosing needs to be based on the physiological
characteristics of the child and the pharmacokinetic parameters of the drug. This review …

Contaminated water supplies at Camp Lejeune: Assessing potential health effects

National Research Council, Division on Earth… - 2009 - books.google.com
In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in
North Carolina were found to be contaminated with the industrial solvents trichloroethylene …

The ontogeny of drug metabolism enzymes and implications for adverse drug events

RN Hines - Pharmacology & therapeutics, 2008 - Elsevier
Profound changes in drug metabolizing enzyme (DME) expression occurs during
development that impacts the risk of adverse drug events in the fetus and child. A review of …

[PDF][PDF] Changes in liver volume from birth to adulthood: a meta‐analysis

TN Johnson, GT Tucker, MS Tanner… - Liver …, 2005 - Wiley Online Library
A diversity of equations is available for the estimation of liver volume (LV), derived from
studies in populations of ethnically homogeneous individuals and using a variety of methods …

Ontogeny of hepatic and renal systemic clearance pathways in infants part I

J Alcorn, PJ McNamara - Clinical pharmacokinetics, 2002 - Springer
Dramatic developmental changes in the physiological and biochemical processes that
govern drug pharmacokinetics and pharmacodynamics occur during the first year of life …

Body surface area as a determinant of pharmacokinetics and drug dosing

M Sawyer, MJ Ratain - Investigational new drugs, 2001 - Springer
Body surface area (BSA) was introduced intomedical oncology in order to derive a
safestarting dose for phase I studies ofanticancer drugs from preclinical animaltoxicology …

A mechanistic approach for the scaling of clearance in children

AN Edginton, W Schmitt, B Voith, S Willmann - Clinical pharmacokinetics, 2006 - Springer
Background and objective Clearance is an important pharmacokinetic concept for scaling
dosage, understanding the risks of drug-drug interactions and environmental risk …