Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …

Monkeypox virus and insights into its immunomodulatory proteins

JR Weaver, SN Isaacs - Immunological reviews, 2008 - Wiley Online Library
Monkeypox is a disease that is endemic in Central and Western Africa. However, in 2003,
there was an outbreak in the United States, representing the first documented monkeypox …

Structural basis for sialic acid–mediated self-recognition by complement factor H

BS Blaum, JP Hannan, AP Herbert, D Kavanagh… - Nature chemical …, 2015 - nature.com
The serum protein complement factor H (FH) ensures downregulation of the complement
alternative pathway, a branch of innate immunity, upon interaction with specific glycans on …

Phase I study of oncolytic vaccinia virus GL-ONC1 in patients with peritoneal carcinomatosis

UM Lauer, M Schell, J Beil, S Berchtold… - Clinical Cancer …, 2018 - AACR
Purpose: Peritoneal carcinomatosis is common in advanced tumor stages or disease
recurrence arising from gastrointestinal cancers, gynecologic malignancies, or primary …

Bitter-sweet symphony: glycan–lectin interactions in virus biology

W Van Breedam, S Pöhlmann… - FEMS microbiology …, 2014 - academic.oup.com
Glycans are carbohydrate modifications typically found on proteins or lipids, and can act as
ligands for glycan-binding proteins called lectins. Glycans and lectins play crucial roles in …

SARS-CoV-2 related antibody-dependent enhancement phenomena in vitro and in vivo

EE Nakayama, T Shioda - Microorganisms, 2023 - mdpi.com
Antibody-dependent enhancement (ADE) is a phenomenon in which antibodies produced in
the body after infection or vaccination may enhance subsequent viral infections in vitro and …

One health: addressing global challenges at the nexus of human, animal, and environmental health

W Mwangi, P de Figueiredo, MF Criscitiello - PLOS pathogens, 2016 - journals.plos.org
It is estimated that 60% of recently emerging human diseases, including HIV-1 and
pandemic influenza, originate from animals [1–4]. The increasing pressures of zoonoses …

Expression of Concern: The pathophysiological and immunological background of the monkeypox virus infection: An update

AG Mukherjee, UR Wanjari… - Journal of Medical …, 2023 - Wiley Online Library
In addition to the COVID‐19 waves, the globe is facing global monkeypox (MPX) outbreak.
MPX is an uncommon zoonotic infection characterized by symptoms similar to smallpox. It is …

Innate immune responses of salmonid fish to viral infections

B Collet - Developmental & Comparative Immunology, 2014 - Elsevier
Viruses are the most serious pathogenic threat to the production of the main aquacultured
salmonid species the rainbow trout Oncorhynchus mykiss and the Atlantic salmon Salmo …

Innate (inherent) control of brain infection, brain inflammation and brain repair: the role of microglia, astrocytes,“protective” glial stem cells and stromal ependymal cells

M Hauwel, E Furon, C Canova, M Griffiths, J Neal… - Brain research …, 2005 - Elsevier
In invertebrates and primitive vertebrates, the brain contains large numbers of “professional”
macrophages associated with neurones, ependymal tanycytes and radial glia to promote …