Endothelial activation: the Ang/Tie axis in sepsis

A Leligdowicz, M Richard-Greenblatt, J Wright… - Frontiers in …, 2018 - frontiersin.org
Sepsis, a dysregulated host response to infection that causes life-threatening organ
dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis …

Malaria-associated acute kidney injury in African children: prevalence, pathophysiology, impact, and management challenges

A Batte, Z Berrens, K Murphy, I Mufumba… - … of Nephrology and …, 2021 - Taylor & Francis
Acute kidney injury (AKI) is emerging as a complication of increasing clinical importance
associated with substantial morbidity and mortality in African children with severe malaria …

Linking EPCR-binding PfEMP1 to brain swelling in pediatric cerebral malaria

A Kessler, S Dankwa, M Bernabeu, V Harawa… - Cell host & …, 2017 - cell.com
Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM). However,
the mechanisms leading to swelling remain poorly defined. Here, we combined …

Investigation of Immune Responses in Giant African Snail, Achatina immaculata, against a Two-Round Lipopolysaccharide Challenge

X Wang, Y Tang, Z Li, Q Wu, X Qiao, F Wan… - International Journal of …, 2023 - mdpi.com
As one of the 100 most-threatening invasive alien species, the giant African snail (Achatina
immaculata) has successfully invaded and established itself in most areas of southern …

The Angiopoietin-Tie2 axis contributes to placental vascular disruption and adverse birth outcomes in malaria in pregnancy

V Tran, AM Weckman, VM Crowley, LS Cahill… - …, 2021 - thelancet.com
Background Malaria during pregnancy is a major contributor to the global burden of adverse
birth outcomes including fetal growth restriction, preterm birth, and fetal loss. Recent …

Endothelial cell protein C receptor-dependent signaling

UR Pendurthi, LVM Rao - Current opinion in hematology, 2018 - journals.lww.com
Endothelial cell protein C receptor-dependent signaling : Current Opinion in Hematology
Endothelial cell protein C receptor-dependent signaling : Current Opinion in Hematology Log …

Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection

B Trent, Y Liang, Y Xing, M Esqueda… - PLoS neglected …, 2020 - journals.plos.org
Orientia tsutsugamushi infection can cause acute lung injury and high mortality in humans;
however, the underlying mechanisms are unclear. Here, we tested a hypothesis that …

[HTML][HTML] Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events

M Chemaly, V McGilligan, M Gibson, M Clauss… - Archives of …, 2017 - Elsevier
Tumour necrosis factor alpha converting enzyme (TACE/ADAM17) is a member of the A
disintegrin and metalloproteinase (ADAM) family of ectodomain shedding proteinases. It …

Host-based prognostic biomarkers to improve risk stratification and outcome of febrile children in low-and middle-income countries

N Balanza, C Erice, M Ngai, R Varo, KC Kain… - Frontiers in …, 2020 - frontiersin.org
Fever is one of the leading causes for pediatric medical consultation and the most common
symptom at clinical presentation in low-and middle-income countries (LMICs). Most febrile …

Plasmodium knowlesi Infection Is Associated With Elevated Circulating Biomarkers of Brain Injury and Endothelial Activation

C Bertran-Cobo, E Dumont, NR Noordin… - The Journal of …, 2024 - academic.oup.com
Background Malaria remains a major public health concern with substantial morbidity and
mortality worldwide. In Malaysia, the emergence of Plasmodium knowlesi has led to a surge …