Fibrosis is observed in nearly every form of myocardial disease. Upon injury, cardiac
fibroblasts in the heart begin to remodel the myocardium by depositing excess extracellular …

The liver represents a unique organ biased toward a tolerogenic milieu. Due to its
anatomical location, it is constantly exposed to microbial and food-derived antigens from the …

The liver is a front‐line immune tissue that plays a major role in the detection, capture and
clearance of pathogens and foreign antigens entering the bloodstream, especially from the …

Background & Aims The hallmarks of chronic HBV infection are a high viral load (HBV DNA)
and even higher levels (> 100-fold in excess of virions) of non-infectious membranous …

Off-tumor targeting of human antigens is difficult to predict in preclinical animal studies and
can lead to serious adverse effects in patients. To address this, we developed a mouse …

Chronic hepatitis B infection (CHB) is an area of high unmet medical need. Current standard-
of-care therapies only rarely lead to a functional cure, defined as durable hepatitis B surface …

Chronic hepatitis B virus (HBV) infection is a serious public health burden, and current
therapies cannot achieve satisfactory cure rate. There are high unmet medical needs of …

Background Currently, standard treatments for chronic hepatitis B such as nucleos (t) ide
analogs (NAs), effectively reduce hepatitis B virus (HBV) loads but rarely result in a …

Although NK cells are classified as innate immune cells, recent studies have demonstrated
the transformation of NK cells into long-lived memory cells that contribute to secondary …

Hepatitis B virus (HBV) infection is a serious global health problem that threatens the health
of human. Tannic acid (TA), a natural polyphenol in foods, fruits, and plants, exhibits a …