Forces generated by cells are critical regulators of cell adhesion, signaling, and function,
and they are also essential drivers in the morphogenetic events of development. Over the …

The way in which a cell migrates is influenced by the physical properties of its surroundings,
in particular the properties of the extracellular matrix. How the physical aspects of the cell's …

Mechanical forces play critical roles in the function of living cells. However, the underlying
mechanisms of how forces influence nuclear events remain elusive. Here, we show that …

The field of stem cells and regenerative medicine offers considerable promise as a means of
delivering new treatments for a wide range of diseases. In order to maximize the …

Cell migration is crucial for cancer dissemination. We find that AMP-activated protein kinase
(AMPK) controls cell migration by acting as an adhesion sensing molecular hub. In 3 …

We describe a technique for the quantitative measurement of cell-generated forces in highly
nonlinear three-dimensional biopolymer networks that mimic the physiological situation of …

Cells generate and sustain mechanical forces within their environment as part of their
normal physiology. They are active materials that can detect mechanical stimulation by the …

One of the most unique physical features of cell adhesion to external surfaces is the active
generation of mechanical force at the cell-material interface. This includes pulling forces …

Adherent cells, crawling slugs, peeling paint, sessile liquid drops, bearings and many other
living and non-living systems apply forces to solid substrates. Traction force microscopy …

Cells generate mechanical forces (traction forces, TFs) while interacting with the
extracellular matrix or neighbouring cells. Forces are generated by both cells and …