Cyclooxygenases are a group of heme-containing isozymes (namely Cox-1 and Cox-2) that
catalyze the conversion of arachidonic acid to largely bioactive prostaglandins (PGs). Cox-1 …

Cyclooxygenase-2 (COX-2), a rate-limiting enzyme converting arachidonic acid to
prostaglandins and a key player in neuroinflammation, has been implicated in the …

An increasing number of studies show that both inflammation and neural plasticity act as key
players in the vulnerability and recovery from psychiatric disorders and neurodegenerative …

Subregional analyses of the hippocampus suggest CA1-dependent memory processes rely
heavily upon interactions between the CA1 subregion and entorhinal cortex. There is …

In the last decade, the potential role of cyclooxygenase-2 (COX-2) and prostaglandins (PGs)
in brain diseases has been extensively studied. COX-2 over-expression has been …

Neuroinflammation is one of the key pathological events involved in the progression of brain
damage caused by cerebral ischemia. Metabolism of arachidonic acid through …

Subregional analyses of the hippocampus have suggested a selective role for the CA1
subregion in intermediate/long‐term spatial memory and consolidation, but not short‐term …

Lipids are essential components of plasma-and organelle-membranes, not only providing a
frame for embedded proteins (eg, receptors and ion channels) but also functioning as …

Alzheimer's disease (AD) is currently treated with cholinergic and glutamatergic therapies,
which provide symptomatic benefit but do not reverse the underlying pathology or cognitive …

Neuro-inflammation is known to initiate the underlying pathogenesis of several
neurodegenerative disorders which may progress to cognitive, behavioral, and functional …