Biomarkers for breast cancer immunotherapy: PD-L1, TILs, and beyond

A Rizzo, AD Ricci - Expert opinion on investigational drugs, 2022 - Taylor & Francis
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) have recently entered into the
therapeutic scenario of metastatic breast cancer. However, only a proportion of patients …

[HTML][HTML] The role of epigenetic modifications in drug resistance and treatment of breast cancer

M Karami Fath, A Azargoonjahromi, A Kiani… - Cellular & Molecular …, 2022 - Springer
Background Breast cancer is defined as a biological and molecular heterogeneous disorder
that originates from breast cells. Genetic predisposition is the most important factor giving …

[HTML][HTML] Triple negative breast cancer treatment options and limitations: future outlook

O Obidiro, G Battogtokh, EO Akala - Pharmaceutics, 2023 - mdpi.com
Triple negative breast cancer (TNBC) has a negative expression of estrogen receptors (ER),
progesterone receptors (PR), and human epidermal growth factor receptors (HER2). The …

Immune-based combinations for metastatic triple negative breast cancer in clinical trials: current knowledge and therapeutic prospects

A Rizzo, AD Ricci, L Lanotte, L Lombardi… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Immune checkpoint inhibitor (ICI) monotherapy appears to be effective in a
small cohort of patients with metastatic triple negative breast cancer (mTNBC). This supports …

A combinatorial delivery of survivin targeted siRNA using cancer selective nanoparticles for triple negative breast cancer therapy

P Kesharwani, A Sheikh, MAS Abourehab… - Journal of Drug Delivery …, 2023 - Elsevier
Triple-negative breast cancer (TNBC) is one major type of cancer for which there has been
no effective therapy to date. An important reason for it being the lack of expression of …

[HTML][HTML] A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer

H Kumar, NV Gupta, R Jain… - Journal of Advanced …, 2023 - Elsevier
Background Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …

[HTML][HTML] Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer

X Ou, Y Tan, J Xie, J Yuan, X Deng, R Shao… - Drug Resistance …, 2024 - Elsevier
Aims This study aims to explore the function and mechanism of G Protein-coupled receptor
class C group 5 member A (GPRC5A) in docetaxel-resistance and liver metastasis of breast …

[HTML][HTML] Advanced phytochemical-based nanocarrier systems for the treatment of breast cancer

VP Chavda, LV Nalla, P Balar, R Bezbaruah… - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer is a concern for the healthcare system. Even with the
advancement of science and technology, the current system for therapeutics and diagnostics …

Chemokines in triple-negative breast cancer heterogeneity: new challenges for clinical implications

U Mehraj, U Mushtaq, MA Mir, A Saleem… - Seminars in Cancer …, 2022 - Elsevier
Tumor heterogeneity is a hallmark of cancer and one of the primary causes of resistance to
therapies. Triple-negative breast cancer (TNBC), which accounts for 15–20% of all breast …

Molecular engineered squaraine nanoprobe for NIR-II/photoacoustic imaging and photothermal therapy of metastatic breast cancer

D Yao, Y Wang, R Zou, K Bian, P Liu… - … applied materials & …, 2020 - ACS Publications
Various squaraine dyes have been developed for biological imaging. Nevertheless,
squaraine dyes with emission in the second window (NIR-II, 1000–1700 nm) have few …