Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms

L Xu, Y Li, Y Dai, J Peng - Pharmacological research, 2018 - Elsevier
Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic
accompany with metabolic and endocrine disorders worldwide. Most of DM patients are …

[HTML][HTML] Diabetic kidney diseases revisited: A new perspective for a new era

H Fu, S Liu, SI Bastacky, X Wang, XJ Tian, D Zhou - Molecular metabolism, 2019 - Elsevier
Background Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal
disease. As the most common microvascular complication of diabetes, DKD is a thorny …

Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy

T Hussain, B Tan, G Murtaza, G Liu, N Rahu… - Pharmacological …, 2020 - Elsevier
Diabetes mellitus type 2 (T2DM) is a metabolic disorder develops due to the overproduction
of free radicals where oxidative stress could contribute it. Possible factors are defective …

Autophagy-nutrient sensing pathways in diabetic complications

UM Parmar, MP Jalgaonkar, YA Kulkarni… - Pharmacological …, 2022 - Elsevier
The incidence of diabetes has been increasing in recent decades which is affecting the
population of both, developed and developing countries. Diabetes is associated with micro …

[HTML][HTML] Mitochondria and T2D: role of autophagy, ER stress, and inflammasome

M Rocha, N Apostolova, R Diaz-Rua, J Muntane… - Trends in Endocrinology …, 2020 - cell.com
Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its
numerous clinical complications are related to mitochondrial dysfunction and oxidative …

[HTML][HTML] Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway

X Sun, D Wang, T Zhang, X Lu, F Duan, L Ju… - Frontiers in …, 2020 - frontiersin.org
Eugenol, as an active compound isolated from Acorus gramineus, has been shown to
protect against cerebral ischemia-reperfusion (I/R) injury. Nonetheless, the detailed …

Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity

I Çakır, CK Hadley, PL Pan, RA Bagchi… - Nature …, 2022 - nature.com
The adipose tissue-derived hormone leptin can drive decreases in food intake while
increasing energy expenditure. In diet-induced obesity, circulating leptin levels rise …

[HTML][HTML] Alzheimer's disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links

M Rojas, M Chávez-Castillo, J Bautista… - World Journal of …, 2021 - ncbi.nlm.nih.gov
At present, Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two highly
prevalent disorders worldwide, especially among elderly individuals. T2DM appears to be …

Autophagy as an emerging target in cardiorenal metabolic disease: from pathophysiology to management

Y Zhang, AT Whaley-Connell, JR Sowers… - Pharmacology & …, 2018 - Elsevier
Although advances in medical technology and health care have improved the early
diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity …

Mitochondrial dysfunction and mitophagy in type 2 diabetes: pathophysiology and therapeutic targets

N Apostolova, T Vezza, J Muntane… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Type 2 diabetes mellitus, which is related to oxidative stress and mitochondrial
dysfunction, is one of the most prevalent diseases in the world. In the past decade …