Inflammatory mediators of asthma: an update
Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …
of many inflammatory and structural cells, all of which release inflammatory mediators that …
Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
M Akdis, S Burgler, R Crameri, T Eiwegger… - Journal of allergy and …, 2011 - Elsevier
Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …
autoimmune diseases, tumor development, organ transplantation, and chronic infections …
Mechanisms of airway hyper‐responsiveness in asthma: the past, present and yet to come
DG Chapman, CG Irvin - Clinical & Experimental Allergy, 2015 - Wiley Online Library
Airway hyper‐responsiveness (AHR) has long been considered a cardinal feature of
asthma. The development of the measurement of AHR 40 years ago initiated many …
asthma. The development of the measurement of AHR 40 years ago initiated many …
Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions
M Toda, DYM Leung, S Molet, M Boguniewicz… - Journal of Allergy and …, 2003 - Elsevier
Background: In atopic dermatitis (AD) there is evidence of tissue fibrosis involving a number
of structural changes, including papillary dermal fibrosis and epidermal hyperplasia. These …
of structural changes, including papillary dermal fibrosis and epidermal hyperplasia. These …
Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma
AJ Ammit, AT Hastie, LC Edsall, RK Hoffman… - The FASEB …, 2001 - Wiley Online Library
Asthma is characterized by airway inflammation, remodeling, and hyperresponsiveness to
contractile stimuli that promote airway constriction and wheezing. Here we present evidence …
contractile stimuli that promote airway constriction and wheezing. Here we present evidence …
TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
C Michaeloudes, MB Sukkar… - … of Physiology-Lung …, 2011 - journals.physiology.org
Reactive oxygen species (ROS) are generated as a result of normal cellular metabolism,
mainly through the mitochondria and peroxisomes, but their release is enhanced by the …
mainly through the mitochondria and peroxisomes, but their release is enhanced by the …
The allergic cascade: review of the most important molecules in the asthmatic lung
K Bloemen, S Verstraelen, R Van Den Heuvel… - Immunology letters, 2007 - Elsevier
Asthma is the most common chronic inflammatory disorder of the airways among children. It
is a complex clinical disease characterized by airway obstruction, airway inflammation and …
is a complex clinical disease characterized by airway obstruction, airway inflammation and …
Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease
P Sheeran, H Jafri, C Carubelli… - The Pediatric …, 1999 - journals.lww.com
Background. Respiratory syncytial virus (RSV) is the most common cause of lower
respiratory tract disease in infants. The role of inflammatory mediators in the pathogenesis of …
respiratory tract disease in infants. The role of inflammatory mediators in the pathogenesis of …
Airway smooth muscle cells: contributing to and regulating airway mucosal inflammation?
KF Chung - European Respiratory Journal, 2000 - Eur Respiratory Soc
In addition to its contractile properties, airway smooth muscle may contribute to the
pathogenesis of asthma by increased proliferation, and by the expression and secretion of …
pathogenesis of asthma by increased proliferation, and by the expression and secretion of …