Deficits in cognition are a core feature of many psychiatric conditions, including
schizophrenia, where the severity of such deficits is a strong predictor of long-term outcome …

The introduction of clinical criteria for the operationalization of psychosis high risk provided a
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …

Background Executive cognitive functions, including working memory, cognitive flexibility,
and inhibition, are impaired in schizophrenia. Executive functions rely on coordinated …

Individuals who abuse substances often differ from nonusers in their brain structure.
Substance abuse and addiction is often associated with atrophy and pathology of grey …

Impaired cortical maturation is a postulated mechanism in the etiology of
neurodevelopmental disorders, including schizophrenia. In the sensory cortex, activity …

Thalamic dysfunction has been implicated in multiple psychiatric disorders. We sought to
study the mechanisms by which abnormalities emerge in the context of the 22q11. 2 …

Identification of reliable biomarkers of prognosis in subjects with high risk to psychosis is an
essential step to improve care and treatment of this population of help-seekers. Longitudinal …

Psychiatry has a well-established tradition of comparing drug-induced experiences to
psychotic symptoms, based on shared phenomena such as altered perceptions. The present …

The thalamic connectivity system, with the thalamus as the central node, enables
transmission of the brain's neural computations via extensive connections to cortical …

Thalamocortical dysfunction is thought to underlie the pathophysiology of chronic pain
revealed by electroencephalographic studies. The thalamus serves as a primary relay …