Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …

Cardiovascular disease is a leading cause of death worldwide. The limited capability of
heart tissue to regenerate has prompted methodological developments for creating de novo …

Alkaline phosphatases (AP) are a class of enzymes that hydrolyze phosphate containing
molecules under alkaline conditions. In humans, there are primarily four different types of …

Recent technological breakthroughs in our ability to derive and differentiate induced
pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all …

Alternative splicing (AS) is an essential mechanism in post-transcriptional regulation and
leads to protein diversity. It has been shown that AS is prevalent in metazoan genomes, and …

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has provided huge
insight into the pathways, mechanisms and transcription factors that control differentiation …

A number of key regulators of mouse embryonic stem (ES) cell identity, including the
transcription factor Nanog, show strong expression fluctuations at the single-cell level. The …

Three-dimensional (3D) genomics shows immense promise for studying X chromosome
inactivation (XCI) by interrogating changes to the X chromosomes' 3D states. Here, we …

The efficiency of pluripotent stem cell differentiation is highly variable, often resulting in
heterogeneous populations that contain undifferentiated cells. Here we developed a …

Simplified culture conditions are essential for large-scale drug screening and medical
applications of human pluripotent stem cells (hPSCs). However, hPSCs [ie, human …