Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …

In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA)
nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the …

Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct
chemical modifications at specific residues on other RNA molecules, primarily on ribosomal …

Covering: 2000 to 2020 The translation of mRNA into proteins is a precisely regulated,
complex process that can be divided into three main stages, ie initiation, elongation …

Ribosomes translate RNA into proteins. The protein synthesis inhibitor cycloheximide (CHX)
is widely used to inhibit eukaryotic ribosomes engaged in translation elongation. However …

Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the
correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity …

Candida albicans is a widespread commensal fungus with substantial pathogenic potential
and steadily increasing resistance to current antifungal drugs. It is known to be resistant to …

Cancer treatment remains a formidable challenge in modern medicine, necessitating a
nuanced understanding of its molecular underpinnings and the identification of novel …

Employed for over half a century to study protein synthesis, cycloheximide (CHX, 1) is a
small molecule natural product that reversibly inhibits translation elongation. More recently …

Saccharomyces cerevisiae Stm1 protein is a ribosomal association factor, which plays an
important role in preserving ribosomes in a nutrition-deprived environment. It is also shown …