Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell
division. Multipolar spindles are often seen in human cancers and are usually associated …

Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are
surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's …

Abstract Background Kinesin superfamily (KIFs) has a long-reported significant influence on
the initiation, development, and progress of breast cancer. However, the prognostic value of …

Chromosomal instability (CIN) is a hallmark of cancer, caused by persistent errors in
chromosome segregation during mitosis. Aggressive cancers like high-grade serous ovarian …

Kinesin-like protein KIFC1, a normally nonessential kinesin motor, plays a critical role in
centrosome clustering in cancer cells and is essential for the survival of cancer cells. Herein …

Breast cancer pathobiology is known to be influenced by the differential expression of a
group of proteins called the kinesin superfamily (KIFs), which is instrumental in the …

Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer
cells often display centrosome amplification. To maintain survival, cancer cells achieve …

Human breast tumors harbor supernumerary centrosomes in almost 80% of tumor cells.
Although amplified centrosomes compromise cell viability via multipolar spindles resulting in …

The kinesin class of microtubule-associated motor proteins present attractive anticancer
targets owing to their roles in key functions in dividing cells. Two interpolar mitotic kinesins …