Mechanisms of MHC class I–restricted antigen processing
E Pamer, P Cresswell - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract Classical class I molecules assemble in the endoplasmic reticulum (ER) with
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …
The nature of the MHC class I peptide loading complex
Peptide binding to major histocompatibility complex (MHC) dass I molecules occurs in the
endoplasmic reticulum (ER). Efficient peptide binding requires a number of components in …
endoplasmic reticulum (ER). Efficient peptide binding requires a number of components in …
Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase …
The large-scale chromatin organization of the major histocompatibility complex and other
regions of chromosome 6 was studied by three-dimensional image analysis in human cell …
regions of chromosome 6 was studied by three-dimensional image analysis in human cell …
The human major histocompatibility complex: lessons from the DNA sequence
S Beck, J Trowsdale - Annual review of genomics and human …, 2000 - annualreviews.org
The entire 3.6-MbpDNA sequence of a human major histocompatibility complex derived
from a composite of DNA clones from different haplotypes, was completed in 1999, primarily …
from a composite of DNA clones from different haplotypes, was completed in 1999, primarily …
[HTML][HTML] Disulfide bond isomerization and the assembly of MHC class I-peptide complexes
The presence of a disulfide bond inside the peptide binding groove of MHC class I
molecules and of the thiol oxidoreductase ERp57 in the class I loading complex suggests …
molecules and of the thiol oxidoreductase ERp57 in the class I loading complex suggests …
Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
Tapasin is a component of the major histocompatibility complex (MHC) class I antigen-
loading complex. Here we show that mice with a disrupted tapasin gene display reduced …
loading complex. Here we show that mice with a disrupted tapasin gene display reduced …
The cell biology of MHC class I antigen presentation
A Williams, CA Peh, T Elliott - Tissue antigens, 2002 - Wiley Online Library
MHC class I antigen presentation refers to the co‐ordinated activities of many intracellular
pathways that promote the cell surface appearance of MHC class I/β2m heterodimers …
pathways that promote the cell surface appearance of MHC class I/β2m heterodimers …
The N‐terminal region of tapasin is required to stabilize the MHC class I loading complex
Tapasin mediates the binding of MHC class I molecules to the transporter associated with
antigen processing (TAP). Deletion mutants of tapasin were used to examine the effect of …
antigen processing (TAP). Deletion mutants of tapasin were used to examine the effect of …
Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading
P Tan, H Kropshofer, O Mandelboim… - The Journal of …, 2002 - journals.aai.org
The ER protein tapasin (Tpn) forms a bridge between MHC class IH chain (HC)/β 2-
microglobulin and the TAP peptide transporter. The function of this TAP-associated complex …
microglobulin and the TAP peptide transporter. The function of this TAP-associated complex …
Accessory proteins and the assembly of human class I MHC molecules: a molecular and structural perspective
M Bouvier - Molecular immunology, 2003 - Elsevier
The cell-surface presentation of antigenic peptides by class I major histocompatibility
complex (MHC) molecules to CD8+ T-cell receptors is part of an immune surveillance …
complex (MHC) molecules to CD8+ T-cell receptors is part of an immune surveillance …