The multiple roles of titin in muscle contraction and force production

W Herzog - Biophysical reviews, 2018 - Springer
Titin is a filamentous protein spanning the half-sarcomere, with spring-like properties in the I-
band region. Various structural, signaling, and mechanical functions have been associated …

Titin as a force-generating muscle protein under regulatory control

JK Freundt, WA Linke - Journal of applied physiology, 2019 - journals.physiology.org
Titin has long been recognized as a mechanical protein in muscle cells that has a main
function as a molecular spring in the contractile units, the sarcomeres. Recent work suggests …

Trapping red blood cells in living animals using optical tweezers

MC Zhong, XB Wei, JH Zhou, ZQ Wang… - Nature communications, 2013 - nature.com
The recent development of non-invasive imaging techniques has enabled the visualization
of molecular events underlying cellular processes in live cells. Although microscopic objects …

Is titin a 'winding filament'? A new twist on muscle contraction

KC Nishikawa, JA Monroy… - … of the royal …, 2012 - royalsocietypublishing.org
Recent studies have demonstrated a role for the elastic protein titin in active muscle, but the
mechanisms by which titin plays this role remain to be elucidated. In active muscle, Ca2+ …

Muscle giants: molecular scaffolds in sarcomerogenesis

A Kontrogianni-Konstantopoulos… - Physiological …, 2009 - journals.physiology.org
Myofibrillogenesis in striated muscles is a highly complex process that depends on the
coordinated assembly and integration of a large number of contractile, cytoskeletal, and …

Mechanisms of enhanced force production in lengthening (eccentric) muscle contractions

W Herzog - Journal of Applied Physiology, 2014 - journals.physiology.org
In contrast to isometric and shortening contractions, many observations made on actively
lengthening muscles cannot be readily explained with the sliding filament and cross-bridge …

Physiological mechanisms of eccentric contraction and its applications: a role for the giant titin protein

AL Hessel, SL Lindstedt, KC Nishikawa - Frontiers in physiology, 2017 - frontiersin.org
When active muscles are stretched, our understanding of muscle function is stretched as
well. Our understanding of the molecular mechanisms of concentric contraction has …

Interrogating biology with force: single molecule high-resolution measurements with optical tweezers

M Capitanio, FS Pavone - Biophysical journal, 2013 - cell.com
Single molecule force spectroscopy methods, such as optical and magnetic tweezers and
atomic force microscopy, have opened up the possibility to study biological processes …

[HTML][HTML] Residual force enhancement following eccentric contractions: a new mechanism involving titin

W Herzog, G Schappacher, M DuVall… - …, 2016 - journals.physiology.org
Eccentric muscle properties are not well characterized by the current paradigm of the
molecular mechanism of contraction: the cross-bridge theory. Findings of force contributions …

Calcium increases titin N2A binding to F-actin and regulated thin filaments

S Dutta, C Tsiros, SL Sundar, H Athar, J Moore… - Scientific reports, 2018 - nature.com
Mutations in titin are responsible for many cardiac and muscle diseases, yet the underlying
mechanisms remain largely unexplained. Numerous studies have established roles for titin …