Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived
proteases and can modulate innate immune mechanisms through its anti-inflammatory …

Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder characterised by reduced
levels of circulating alpha-1 antitrypsin and an increased risk of lung and liver disease …

慢性阻塞性肺疾病(慢阻肺) 全球倡议(global initiative for chronic obstructive lung disease,
GOLD) 2022 年修订版于2021-11-15 发布, 总体来说其对于慢阻肺的诊断, 评估 …

Rationale: Intravenous plasma-purified alpha-1 antitrypsin (IV-AAT) has been used as
therapy for alpha-1 antitrypsin deficiency (AATD) since 1987. Previous trials (RAPID and …

Objective Alpha-1 antitrypsin deficiency (AATD) is a common, potentially lethal inborn
disorder caused by mutations in alpha-1 antitrypsin (AAT). Homozygosity for the 'Pi …

Summary Background Alpha-1 Antitrypsin (AAT) deficiency (AATD), the most common
genetic cause of emphysema presents with unexplained phenotypic heterogeneity in …

Introduction Alpha1 antitrypsin deficiency (AATD), a common hereditary disorder affecting
mainly lungs, liver and skin has been the focus of some of the most exciting therapeutic …

Alpha-1 antitrypsin (AAT) is the most abundant serine proteinase inhibitor in human plasma.
When Laurell and Erikson 1 first noted the association between a deficiency of the protein …

Abstract Alpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease
associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of …

The ZZ genotype of alpha-1 antitrypsin deficiency (AATD) is strongly associated with COPD,
even in never-smokers. Moderate AATD genotypes (MZ and SZ) have been shown to …