Sea anemones: Quiet achievers in the field of peptide toxins
Sea anemones have been understudied as a source of peptide and protein toxins, with
relatively few examined as a source of new pharmacological tools or therapeutic leads. This …
relatively few examined as a source of new pharmacological tools or therapeutic leads. This …
Peptide blockers of Kv1. 3 channels in T cells as therapeutics for autoimmune disease
Highlights•The K v 1.3 channel in T cells is a validated therapeutic target for autoimmune
diseases.•The most potent blockers are peptides from scorpions and sea anemones.•Phase …
diseases.•The most potent blockers are peptides from scorpions and sea anemones.•Phase …
The voltage-gated potassium channel KV1. 3 as a therapeutic target for venom-derived peptides
The voltage-gated potassium channel KV 1.3 is a well-established therapeutic target for a
range of autoimmune diseases, in addition to being the site of action of many venom-derived …
range of autoimmune diseases, in addition to being the site of action of many venom-derived …
Alchemical Free Energy Calculations on Membrane-Associated Proteins
Membrane proteins have diverse functions within cells and are well-established drug
targets. The advances in membrane protein structural biology have revealed drug and lipid …
targets. The advances in membrane protein structural biology have revealed drug and lipid …
Venom-derived peptide inhibitors of voltage-gated potassium channels
Voltage-gated potassium channels play a key role in human physiology and pathology.
Reflecting their importance, numerous channelopathies have been characterised that arise …
Reflecting their importance, numerous channelopathies have been characterised that arise …
Prolonged immunomodulation in inflammatory arthritis using the selective Kv1. 3 channel blocker HsTX1 [R14A] and its PEGylated analog
MR Tanner, RB Tajhya, R Huq, EJ Gehrmann… - Clinical …, 2017 - Elsevier
Effector memory T lymphocytes (T EM cells) that lack expression of CCR7 are major drivers
of inflammation in a number of autoimmune diseases, including multiple sclerosis and …
of inflammation in a number of autoimmune diseases, including multiple sclerosis and …
A potent and Kv1. 3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases
HsTX1 toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally
amidated peptide cross-linked by four disulfide bridges. Here we describe new HsTX1 …
amidated peptide cross-linked by four disulfide bridges. Here we describe new HsTX1 …
Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family
Abstract Background The ShK toxin from Stichodactyla helianthus has established the
therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin …
therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin …
Development of highly selective Kv1. 3-blocking peptides based on the sea anemone peptide ShK
MW Pennington, SC Chang, S Chauhan, R Huq… - Marine Drugs, 2015 - mdpi.com
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide
that blocks the voltage-gated potassium channel Kv1. 3 at ca. 10 pM and the related channel …
that blocks the voltage-gated potassium channel Kv1. 3 at ca. 10 pM and the related channel …
Modelling peptide–protein complexes: docking, simulations and machine learning
Peptides mediate up to 40% of protein interactions, their high specificity and ability to bind in
places where small molecules cannot make them potential drug candidates. However …
places where small molecules cannot make them potential drug candidates. However …