Neurological conditions, including cognitive impairment and Alzheimer's disease (AD),
impose a huge burden on society, affecting millions of people globally. In addition to genetic …

Animal studies over the past two decades have led to extensive advances in our
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …

Schizophrenia research arose in the twentieth century and is currently rapidly developing,
focusing on many parallel research pathways and evaluating various concepts of disease …

Exposure to stressors in early postnatal life induces long-lasting modifications in brain
function. This plasticity, an essential characteristic of the brain that enables adaptation to the …

Background Early life stress is a major risk factor for later development of psychiatric
disorders, including post-traumatic stress disorder (PTSD). An intricate relationship exists …

Early-life stress (ELS) is a risk factor for a variety of neuropsychiatric disturbances, including
anxiety and depression. ELS in the form of maternal deprivation (MD) can be linked also to …

Early child maltreatment, such as child abuse and neglect, is well known to affect the
development of social skills. However, the mechanisms by which such an adverse …

Abstract Toll-like Receptors (TLRs) are implicated with the pathogenesis of cognitive
impairment induced by inflammation. Early life stress is associated with altered trajectories …

Stressful events experienced during early life are associated with increased vulnerability of
developing psychopathology in adulthood. In the present study, we exposed 9-day-old …

Early life stress negatively impacts brain development and affects structure and function of
parvalbumin immunopositive (PV+) inhibitory neurons. Main regulators of PV+ interneurons …