There is currently little information available about how individual cell types contribute to
Alzheimer's disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …

Molecular interaction networks lay the foundation for studying how biological functions are
controlled by the complex interplay of genes and proteins. Investigating perturbed processes …

Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely
unexplored phenotype and development. We used single-cell RNA-seq to characterize …

Gene regulatory networks, in which differential expression of regulator genes induce
differential expression of their target genes, underlie diverse biological processes such as …

Background & Aims The enteric mycobiota is a major component of the human gut
microbiota, but its role in colorectal cancer (CRC) remains largely elusive. We conducted a …

Huntington Disease (HD) is an inherited movement disorder caused by expanded CAG
repeats in the Huntingtin gene. We have used single nucleus RNASeq (snRNASeq) to …

Background The skin harbors complex communities of resident microorganisms, yet little is
known of their physiological roles and the molecular mechanisms that mediate cutaneous …

The antitumor action of immune checkpoint blockade (ICB) is primarily mediated by CD8+ T
cells. How sensitivity to ICB varies across CD8+ T cell subsets and clonotypes and the …

Several enteric pathogens can gain specific metabolic advantages over other members of
the microbiota by inducing host pathology and inflammation. The pathogen Clostridium …

Background The emergence of antimicrobial resistance is a major threat to global health
and has placed pressure on the livestock industry to eliminate the use of antibiotic growth …