The role of neuroimmune signaling in alcoholism
Alcohol consumption and stress increase brain levels of known innate immune signaling
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …
[HTML][HTML] Glial and neuroimmune mechanisms as critical modulators of drug use and abuse
Drugs of abuse cause persistent alterations in synaptic plasticity that may underlie addiction
behaviors. Evidence suggests glial cells have an essential and underappreciated role in the …
behaviors. Evidence suggests glial cells have an essential and underappreciated role in the …
The etiologic, theory-based, ontogenetic hierarchical framework of alcohol use disorder: A translational systematic review of reviews.
Abstract Modern nosologies (eg, International Classification of Diseases, 11th edition [ICD-
11], Diagnostic and Statistical Manual of Mental Disorders, 5th edition [DSM–5]) for alcohol …
11], Diagnostic and Statistical Manual of Mental Disorders, 5th edition [DSM–5]) for alcohol …
[HTML][HTML] Mechanisms of neuroimmune gene induction in alcoholism
FT Crews, RP Vetreno - Psychopharmacology, 2016 - Springer
Rationale Alcoholism is a primary, chronic relapsing disease of brain reward, motivation,
memory, and related circuitry. It is characterized by an individual's continued drinking …
memory, and related circuitry. It is characterized by an individual's continued drinking …
Induction of innate immune genes in brain create the neurobiology of addiction
FT Crews, J Zou, L Qin - Brain, behavior, and immunity, 2011 - Elsevier
Addiction occurs through repeated abuse of drugs that progressively reduce behavioral
control and cognitive flexibility while increasing limbic negative emotion. Recent discoveries …
control and cognitive flexibility while increasing limbic negative emotion. Recent discoveries …
[HTML][HTML] Neuroimmune function and the consequences of alcohol exposure
Induction of neuroimmune genes by binge drinking increases neuronal excitability and
oxidative stress, contributing to the neurobiology of alcohol dependence and causing …
oxidative stress, contributing to the neurobiology of alcohol dependence and causing …
[HTML][HTML] NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
L Qin, FT Crews - Journal of neuroinflammation, 2012 - Springer
Background Activation of microglia causes the production of proinflammatory factors and
upregulation of NADPH oxidase (NOX) that form reactive oxygen species (ROS) that lead to …
upregulation of NADPH oxidase (NOX) that form reactive oxygen species (ROS) that lead to …
[HTML][HTML] Toll-like receptor signaling and stages of addiction
Abstract Background Athina Markou and her colleagues discovered persistent changes in
adult behavior following adolescent exposure to ethanol or nicotine consistent with …
adult behavior following adolescent exposure to ethanol or nicotine consistent with …
Molecular mechanisms underlying alcohol-drinking behaviours
D Ron, S Barak - Nature Reviews Neuroscience, 2016 - nature.com
The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …
alcohol despite the negative consequences. The transition from the moderate use of alcohol …
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is
largely unknown, despite its clinical and societal importance. We report a genome-wide …
largely unknown, despite its clinical and societal importance. We report a genome-wide …