Progesterone receptor membrane component 1 (PGRMC1) contains a cytochrome b5
domain fold and belongs to the so-called membrane-associated progesterone receptor …

Oligodendrocytes (OLs) are particularly susceptible to the toxicity of the acute lesion
environment after spinal cord injury (SCI). They undergo both necrosis and apoptosis …

Macrophages dominate sites of CNS injury in which they promote both injury and repair.
These divergent effects may be caused by distinct macrophage subsets, ie,“classically …

The wound healing process that occurs after spinal cord injury is critical for maintaining
tissue homeostasis and limiting tissue damage, but eventually results in a scar-like …

Experimental and clinical data have demonstrated that activating the immune system in the
CNS can be destructive. However, other studies have shown that enhancing an immune …

The immune response that accompanies spinal cord injury contributes to both injury and
reparative processes. It is this duality that is the focus of this review. Here, we consider the …

Neurons and oligodendrocytes are highly vulnerable to various insults, and their
spontaneous replacement occurs to only a limited extent after damage in the adult spinal …

Basic science advances in spinal cord injury and regeneration research have led to a variety
of novel experimental therapeutics designed to promote functionally effective axonal …

Trauma to the spinal cord causes permanent disability to more than 180,000 people every
year worldwide. The initial mechanical damage triggers a complex set of secondary events …

The cell cycle is a delicately manipulated process essential for the development,
differentiation, proliferation and death of cells. Inappropriate activation of cell cycle …