Trends in insulin resistance: insights into mechanisms and therapeutic strategy

M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

[HTML][HTML] Current trends in epidemiology of cardiovascular disease and cardiovascular risk management in type 2 diabetes

JS Yun, SH Ko - Metabolism, 2021 - Elsevier
With the advances in diabetes care, the trend of incident cardiovascular disease (CVD) in
patients with type 2 diabetes mellitus (T2DM) has been decreasing over past decades …

The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study

S Hong, K Han, CY Park - BMC medicine, 2020 - Springer
Abstract Background The triglyceride glucose (TyG) index is an inexpensive clinical
surrogate marker for insulin resistance. However, the relationship between TyG index and …

Insulin resistance and atherosclerosis: implications for insulin-sensitizing agents

A Di Pino, RA DeFronzo - Endocrine reviews, 2019 - academic.oup.com
Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular
complications, which represent the major cause of mortality. Despite effective treatment of …

Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome

L Wang, H Cong, J Zhang, Y Hu, A Wei… - Cardiovascular …, 2020 - Springer
Background The triglyceride-glucose index (TyG index) has been regarded as a reliable
alternative marker of insulin resistance and an independent predictor of cardiovascular …

The effects of high‐intensity interval training on glucose regulation and insulin resistance: a meta‐analysis

C Jelleyman, T Yates, G O'Donovan, LJ Gray… - Obesity …, 2015 - Wiley Online Library
The aim of this meta‐analysis was to quantify the effects of high‐intensity interval training
(HIIT) on markers of glucose regulation and insulin resistance compared with control …

Association between macro-and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study

S Zhao, S Yu, C Chi, X Fan, J Tang, H Ji… - Cardiovascular …, 2019 - Springer
Background It has been reported that the triglyceride-glucose (TyG) index may serve as a
simple and credible surrogate marker of insulin resistance (IR). However, its association with …

Insulin resistance is a cardiovascular risk factor in humans

MM Adeva-Andany, J Martínez-Rodríguez… - Diabetes & Metabolic …, 2019 - Elsevier
Diabetes is a common metabolic disorder associated to elevated cardiovascular morbidity
and mortality that is not explained by hyperglycemia or traditional cardiovascular risk factors …

Pioglitazone: the forgotten, cost-effective cardioprotective drug for type 2 diabetes

RA DeFronzo, S Inzucchi… - Diabetes and …, 2019 - journals.sagepub.com
Type 2 diabetes individuals are at high risk for macrovascular complications: myocardial
infarction, stroke and cardiovascular mortality. Recent cardiovascular outcome trials have …

The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic …

HM Park, HS Lee, YJ Lee, JH Lee - Diabetes research and clinical practice, 2021 - Elsevier
Aims Insulin resistance is an independent risk factor for developing type 2 diabetes.
Therefore, this study compared the predictability of the triglyceride–glucose (TyG) index and …