Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …

As humans evolved, perhaps the two strongest selection determinants of survival were a
robust immune response able to clear bacterial, viral, and parasitic infection and an ability to …

Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …

Acetylation is increasingly recognized as an important metabolic regulatory posttranslational
protein modification, yet the metabolic consequence of mitochondrial protein …

Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the
United States and includes a spectrum of disease that includes simple steatosis, non …

The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

Mitochondria play central roles in ATP production, energy expenditure, and disposal of ROS.
Excessive energy substrates lead to mitochondrial dysfunction with consequential effects on …

Mitochondria play central roles in energy homeostasis, metabolism, signaling, and
apoptosis. Accordingly, the abundance, morphology, and functional properties of …

This review highlights the inflammatory and insulin-antagonizing effects of saturated fatty
acids (SFA), which contribute to the development of metabolic syndrome. Mechanisms …

Peripheral arterial disease (PAD) affects 5 million people in the US and is the primary cause
of limb amputations. Exercise remains the single best intervention for PAD, in part thought to …