Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
Mid-infrared spectroscopy for protein analysis: potential and challenges
ÁI López-Lorente, B Mizaikoff - Analytical and bioanalytical chemistry, 2016 - Springer
Mid-infrared (MIR) spectroscopy investigates the interaction of MIR photons with both
organic and inorganic molecules via the excitation of vibrational and rotational modes …
organic and inorganic molecules via the excitation of vibrational and rotational modes …
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ
S Dharmaiah, L Bindu, TH Tran… - Proceedings of the …, 2016 - National Acad Sciences
Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are
essential for its interaction with the plasma membrane where KRAS-mediated signaling …
essential for its interaction with the plasma membrane where KRAS-mediated signaling …
Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins
RAS is a signaling protein associated with the cell membrane that is mutated in up to 30% of
human cancers. RAS signaling has been proposed to be regulated by dynamic …
human cancers. RAS signaling has been proposed to be regulated by dynamic …
Oncogenic Ras isoforms signaling specificity at the membrane
R Nussinov, CJ Tsai, H Jang - Cancer research, 2018 - AACR
How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas,
HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How …
HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How …
Markov state models and molecular dynamics simulations reveal the conformational transition of the intrinsically disordered hypervariable region of K-Ras4B to the …
K-Ras4B, the most frequently mutated Ras isoform in human tumors, plays a vital part in cell
growth, differentiation, and survival. Its tail, the C-terminal hypervariable region (HVR), is …
growth, differentiation, and survival. Its tail, the C-terminal hypervariable region (HVR), is …
Palmitoylation as a key regulator of ras localization and function
C Busquets-Hernández, G Triola - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Ras proteins require membrane association for proper function. This process is tightly
regulated by reversible palmitoylation that controls not only the distribution over different …
regulated by reversible palmitoylation that controls not only the distribution over different …
Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions
WK Gillette, D Esposito, M Abreu Blanco… - Scientific reports, 2015 - nature.com
Prenylated proteins play key roles in several human diseases including cancer,
atherosclerosis and Alzheimer's disease. KRAS4b, which is frequently mutated in …
atherosclerosis and Alzheimer's disease. KRAS4b, which is frequently mutated in …
Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane
B Lakshman, S Messing, EM Schmid… - Journal of Biological …, 2019 - ASBMB
The gene encoding the GTPase KRAS is frequently mutated in pancreatic, lung, and
colorectal cancers. The KRAS fraction in the plasma membrane (PM) correlates with …
colorectal cancers. The KRAS fraction in the plasma membrane (PM) correlates with …
[HTML][HTML] Peptide and protein binding to lipid monolayers studied by FT-IRRA spectroscopy
A Blume, A Kerth - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2013 - Elsevier
Lipid monolayers at the air–water interface represent half of a lipid bilayer and are therefore
suitable model systems for studying the binding of peripheral proteins and polypeptides as …
suitable model systems for studying the binding of peripheral proteins and polypeptides as …