The molecular hallmarks of the serrated pathway in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing …
challenging clinical management. Through a large series of whole-genome sequencing …
[HTML][HTML] Development and validation of a weakly supervised deep learning framework to predict the status of molecular pathways and key mutations in colorectal …
Background Determining the status of molecular pathways and key mutations in colorectal
cancer is crucial for optimal therapeutic decision making. We therefore aimed to develop a …
cancer is crucial for optimal therapeutic decision making. We therefore aimed to develop a …
Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers
IG Serebriiskii, V Pavlov, R Tricarico… - Nature …, 2022 - nature.com
Loss of expression or activity of the tumor suppressor PTEN acts similarly to an activating
mutation in the oncogene PIK3CA in elevating intracellular levels of phosphatidylinositol (3 …
mutation in the oncogene PIK3CA in elevating intracellular levels of phosphatidylinositol (3 …
Driver gene mutations and epigenetics in colorectal cancer
H Raskov, JH Søby, J Troelsen, RD Bojesen… - Annals of …, 2020 - journals.lww.com
Objective: The majority of patients with colorectal cancer are diagnosed with locally
advanced and/or disseminated disease, and treatment options include surgery in …
advanced and/or disseminated disease, and treatment options include surgery in …
Colorectal cancer: from genetic landscape to targeted therapy
M El Bali, J Bakkach, M Bennani Mechita - Journal of Oncology, 2021 - Wiley Online Library
Colorectal cancer (CRC) is the third most common cancer type and the second cause of
death worldwide. The advancement in understanding molecular pathways involved in CRC …
death worldwide. The advancement in understanding molecular pathways involved in CRC …
Phenolic phytochemicals for prevention and treatment of colorectal cancer: A critical evaluation of in vivo studies
S De, S Paul, A Manna, C Majumder, K Pal, N Casarcia… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is a significant cause of death worldwide. The
inefficacy of the current treatment regimens is reflected in the frequent recurrence and …
inefficacy of the current treatment regimens is reflected in the frequent recurrence and …
Back to the colorectal cancer consensus molecular subtype future
DG Menter, JS Davis, BM Broom, MJ Overman… - Current …, 2019 - Springer
Abstract Purpose of Review This review seeks to provide an informed prospective on the
advances in molecular profiling and analysis of colorectal cancer (CRC). The goal is to …
advances in molecular profiling and analysis of colorectal cancer (CRC). The goal is to …
Genomic landscape of colorectal carcinogenesis
JC Kim, WF Bodmer - Journal of cancer research and clinical oncology, 2022 - Springer
Purpose The molecular pathogenesis of solid tumour was first assessed in colorectal cancer
(CRC). To date,≤ 100 genes with somatic alterations have been found to inter-connectively …
(CRC). To date,≤ 100 genes with somatic alterations have been found to inter-connectively …