Standard induction chemotherapy, consisting of an anthracycline and cytarabine, has been
the first-line therapy for many years to treat acute myeloid leukemia (AML). Although this …

Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …

YTHDC1 has distinct functions as a nuclear N 6-methyladenosine (m6A) reader in
regulating RNA metabolism. Here we show that YTHDC1 is overexpressed in acute myeloid …

Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological
malignancy. Relapse and refractory after induction chemotherapy are still challenges for …

A facile method was designed that can specifically deliver CRISPR/Cas9 into target cells
nuclei and reduce the off-target effects. A multifunctional delivery vector for FOXM1 knockout …

Background Maintenance of cancer stem‐like cell (CSC) stemness supported by aberrantly
regulated cancer cell metabolism is critical for CSC self‐renewal and tumor progression. As …

The transcription factor MYB proto-oncogene like 2 (MYBL2) is critical in regulating gene
expression and tumorigenesis. However, the biological function of MYBL2 in bladder cancer …

Abstract Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate
growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks …

Genome-wide binding profiles of estrogen receptor (ER) and FOXA1 reflect cancer state in
ER+ breast cancer. However, routine profiling of tumor transcription factor (TF) binding is …

Forkhead box (FOX) protein M1 (FOXM1) is a critical proliferation-associated transcription
factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also …