HLA variation and SARS-CoV-2 specific antibody response

D Wolday, CYJ Fung, G Morgan, S Casalino… - Viruses, 2023 - mdpi.com
Differences in SARS-CoV-2-specific immune responses have been observed between
individuals following natural infection or vaccination. In addition to already known factors …

[HTML][HTML] A systematic scoping review of the genetic ancestry of the Brazilian population

AM Souza, SS Resende, TN Sousa… - Genetics and Molecular …, 2019 - SciELO Brasil
The genetic background of the Brazilian population is mainly characterized by three parental
populations: European, African, and Native American. The aim of this study was to overview …

DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability

CHM Rodrigues, DEV Pires… - Nucleic acids research, 2018 - academic.oup.com
Proteins are highly dynamic molecules, whose function is intrinsically linked to their
molecular motions. Despite the pivotal role of protein dynamics, their computational …

Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam

KE Holt, P McAdam, PVK Thai, NTT Thuong, DTM Ha… - Nature …, 2018 - nature.com
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …

mCSM-membrane: predicting the effects of mutations on transmembrane proteins

DEV Pires, CHM Rodrigues… - Nucleic Acids Research, 2020 - academic.oup.com
Significant efforts have been invested into understanding and predicting the molecular
consequences of mutations in protein coding regions, however nearly all approaches have …

The immunology of Plasmodium vivax malaria

LR Antonelli, C Junqueira, JM Vinetz… - Immunological …, 2020 - Wiley Online Library
Plasmodium vivax infection, the predominant cause of malaria in Asia and Latin America,
affects~ 14 million individuals annually, with considerable adverse effects on wellbeing and …

mCSM–NA: predicting the effects of mutations on protein–nucleic acids interactions

DEV Pires, DB Ascher - Nucleic acids research, 2017 - academic.oup.com
Over the past two decades, several computational methods have been proposed to predict
how missense mutations can affect protein structure and function, either by altering protein …

[HTML][HTML] Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies

RO Payne, SE Silk, SC Elias, KH Milne, TA Rawlinson… - JCI insight, 2017 - ncbi.nlm.nih.gov
BACKGROUND. Plasmodium vivax is the most widespread human malaria geographically;
however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite …

Structure guided prediction of Pyrazinamide resistance mutations in pncA

M Karmakar, CHM Rodrigues, K Horan, JT Denholm… - Scientific reports, 2020 - nature.com
Pyrazinamide plays an important role in tuberculosis treatment; however, its use is
complicated by side-effects and challenges with reliable drug susceptibility testing …

Duffy 血型抗原的G-蛋白偶联受体作用

张志琴, 李树中, 李中华, 张黎雯 - 临床血液学杂志, 2019 - whuhzzs.com
Duffy 抗原是红细胞膜表面抗原, 属于红细胞系统抗原. 抗原表达在Fy 糖蛋白的膜外环上. G
蛋白偶联受体, 是指G 蛋白的受体作用. 表达Duffy 抗原的Fy 糖蛋白就是一种G 蛋白 …