Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular
responses to DNA damage. This feature of malignant cells opens new avenues for tumor …

Head and neck cancer (HNC) is a term collectively used to describe a heterogeneous group
of tumors that arise in the oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx …

Simple Summary The MRN Complex (MRE11-RAD50-NBS1) is responsible for initiating
DNA double-strand break repair and activating several downstream proteins. These proteins …

As cells age and are exposed to genotoxic stress, preservation of the genomic code requires
multiple DNA repair pathways to remove single‐strand or double‐strand breaks. Loss of …

Poly (ADP‐ribose) polymerase (PARP) inhibitors have proven to be successful agents in
inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached …

PARP inhibitors (PARPi) are potentially effective therapeutic agents capable of inducing
synthetic lethality in tumors with deficiencies in homologous recombination (HR)-mediated …

Background Poly (ADP-ribose) polymerase inhibitors (PARPis) can effectively treat ovarian
cancer patients with defective homologous recombination (HR). Loss or dysfunction of …

Simple Summary Defects in MRE11A/RAD50/NBS1 (MRN) genes and overexpression of the
MRN proteins are both linked to cancer, generating confusion about how the MRN complex …

Context Radiation is a key arm in the multidisciplinary treatment of patients with head and
neck squamous cell carcinoma. During the past 2 decades, significant changes in the way …