Lactosylceramide (LacCer), also known as CD17/CDw17, is a member of a large family of
small molecular weight compounds known as glycosphingolipids. It plays a pivotal role in …

Sphingolipids, such as sphingomyelins, ceramides, glycosphingolipids, and sphingosine-1-
phosphates (S1P) are a large group of structurally and functionally diverse molecules. Some …

Introduction Sphingolipids are a diverse class of lipids with various roles in cell functions
and subclasses such as ceramides have been associated with cardiovascular diseases …

A significant population of patients with chronic kidney disease (CKD) develops cardiac
hypertrophy, which can lead to heart failure and sudden cardiac death. Soluble klotho (sKL) …

BACKGROUND: Dysregulated metabolism of bioactive sphingolipids, including ceramides
and sphingosine-1-phosphate, has been implicated in cardiovascular disease, although the …

Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia,
promotes the formation of atheromatous plaques in large vessels of the cardiovascular …

Metabolic syndrome (MetS) is a multicomponent risk condition that reflects the clustering of
individual cardiometabolic risk factors related to abdominal obesity and insulin resistance …

Cardiovascular disease (CVD) remains a leading cause of death globally. Understanding
and characterizing the biochemical context of the cardiovascular system in health and …

This review explores the crucial role of glycosphingolipids (GSLs) in the context of
cardiovascular diseases (CVDs), focusing on their biosynthesis, metabolic pathways, and …

Background Left ventricular hypertrophy (LVH) is an important risk factor for cardiovascular
and all-cause mortality. Previous studies reported conflicting results concerning the …