Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

Arginine methylation is a ubiquitous post-translational modification. Three predominant
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …

INTRODUCTION The complete sequence of animal genomes has had a transformative
impact on biological research. Whereas the genome sequence of an organism contains the …

The tight control of gene expression at the level of both transcription and post-transcriptional
RNA processing is essential for mammalian development. We here investigate the role of …

Abstract Background The freshwater planarian Schmidtea mediterranea has emerged as a
powerful model for studies of regenerative, stem cell, and germ cell biology. Whole-mount in …

Background The ability to assess gene function is essential for understanding biological
processes. Currently, RNA interference (RNAi) is the only technique available to assess …

Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

Having an almost unlimited capacity to regenerate tissues lost to age and injury, planarians
have long fascinated naturalists. In the Western hemisphere alone, their documented history …

Planarian flatworms are in the midst of a renaissance as a model system for regeneration
and stem cells. Besides two well-studied model species, hundreds of species exist …

Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic
reprogramming, which includes comprehensive DNA demethylation. We found that PRMT5 …