[HTML][HTML] Molecular mediators of RNA loading into extracellular vesicles
C Corrado, MM Barreca, C Zichittella, R Alessandro… - Cells, 2021 - mdpi.com
In the last decade, an increasing number of studies have demonstrated that non-coding
RNA (ncRNAs) cooperate in the gene regulatory networks with other biomolecules …
RNA (ncRNAs) cooperate in the gene regulatory networks with other biomolecules …
[HTML][HTML] Extracellular vesicles for therapeutic nucleic acid delivery: loading strategies and challenges
A Oshchepkova, M Zenkova, V Vlassov - International Journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by
cells of various origins. They contain different biological cargoes, protecting them from …
cells of various origins. They contain different biological cargoes, protecting them from …
Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia
N Korvenlaita, M Gómez‐Budia… - Journal of …, 2023 - Wiley Online Library
Hypoxia induces changes in the secretion of extracellular vesicles (EVs) in several non‐
neuronal cells and pathological conditions. EVs are packed with biomolecules, such as …
neuronal cells and pathological conditions. EVs are packed with biomolecules, such as …
[HTML][HTML] Diagnostic circulating miRNAs in sporadic amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the neurodegeneration of motoneurons. About 10% of ALS is hereditary and involves …
the neurodegeneration of motoneurons. About 10% of ALS is hereditary and involves …
[HTML][HTML] Transfer of cardiomyocyte-derived extracellular vesicles to neighboring cardiac cells requires tunneling nanotubes during heart development
T Chen, DG Ellman, S Fang, ST Bak, MØ Nørgård… - Theranostics, 2024 - ncbi.nlm.nih.gov
Abstract Rationale: Extracellular vesicles (EVs) are thought to mediate intercellular
communication during development and disease. Yet, biological insight to intercellular EV …
communication during development and disease. Yet, biological insight to intercellular EV …
[HTML][HTML] Extracellular vesicle small RNA cargo discriminates non-cancer donors from pediatric B-lymphoblastic leukemia patients
MN Longjohn, JABJ Hudson, L Peña-Castillo… - Frontiers in …, 2023 - frontiersin.org
Pediatric B-acute lymphoblastic leukemia (B-ALL) is a disease of abnormally growing B
lymphoblasts. Here we hypothesized that extracellular vesicles (EVs), which are nanosized …
lymphoblasts. Here we hypothesized that extracellular vesicles (EVs), which are nanosized …
[HTML][HTML] Ribonuclease activity undermines immune sensing of naked extracellular RNA
M Castellano, V Blanco, ML Calzi, B Costa, K Witwer… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The plasma membrane and the membrane of endosomal vesicles are considered physical
barriers preventing extracellular RNA uptake. While naked RNA can be spontaneously …
barriers preventing extracellular RNA uptake. While naked RNA can be spontaneously …
[HTML][HTML] Revealing the grammar of small RNA secretion using interpretable machine learning
Small non-coding RNAs can be secreted through a variety of mechanisms, including
exosomal sorting, in small extracellular vesicles, and within lipoprotein complexes …
exosomal sorting, in small extracellular vesicles, and within lipoprotein complexes …
[HTML][HTML] Identification of RNA-based cell-type markers for stem-cell manufacturing systems with a statistical scoring function
Cell-type biomarkers are useful in stem-cell manufacturing to monitor cell purity, quantity,
and quality. However, the study on cell-type markers, specifically for stem cell manufacture …
and quality. However, the study on cell-type markers, specifically for stem cell manufacture …
Systemwide in vivo, multi-omics and computational approaches to understand tumor immune coevolution and RNA secretion
B Zirak - 2024 - escholarship.org
Tumor progression is the major cause of death in cancer patients. Due to their higher
chromosomal instability and other genomic alterations, tumors evolve rapidly in response to …
chromosomal instability and other genomic alterations, tumors evolve rapidly in response to …