The SLC22 family with transporters of organic cations, anions and zwitterions
H Koepsell - Molecular aspects of medicine, 2013 - Elsevier
The SLC22 family contains 13 functionally characterized human plasma membrane proteins
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
The solute carrier (SLC) superfamily encompasses a large variety of membrane-bound
transporters required to transport a diverse array of substrates over biological membranes …
transporters required to transport a diverse array of substrates over biological membranes …
Tissues, metabolic pathways and genes of key importance in lactating dairy cattle
S Nayeri, P Stothard - Springer Science Reviews, 2016 - Springer
Milk and dairy products are valuable sources of food for humans. Increased milk yield and
changes in milk composition in dairy cows have been achieved through a variety of means …
changes in milk composition in dairy cows have been achieved through a variety of means …
Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation
G Schlegel, J Keller, F Hirche, S Geißler… - BMC veterinary …, 2012 - Springer
Background In rodents and pigs, it has shown that carnitine synthesis and uptake of
carnitine into cells are regulated by peroxisome proliferator-activated receptor α (PPARA), a …
carnitine into cells are regulated by peroxisome proliferator-activated receptor α (PPARA), a …
Non-clinical models to determine drug passage into human breast milk
Background: Successful practice of clinical perinatal pharmacology requires a thorough
understanding of the pronounced physiological changes during lactation and how these …
understanding of the pronounced physiological changes during lactation and how these …
Lactation stage‐dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids
SE Gilchrist, J Alcorn - Fundamental & clinical pharmacology, 2010 - Wiley Online Library
Since solute carrier (SLC) and ATP‐binding cassette (ABC) transporters play pivotal roles in
the transport of both nutrients and drugs into breast milk, drug–nutrient transport interactions …
the transport of both nutrients and drugs into breast milk, drug–nutrient transport interactions …
The functional and molecular entities underlying amino acid and peptide transport by the mammary gland under different physiological and pathological conditions
DB Shennan, CAR Boyd - Journal of mammary gland biology and …, 2014 - Springer
This review describes the properties and regulation of the membrane transport proteins
which supply the mammary gland with aminonitrogen to support metabolism under different …
which supply the mammary gland with aminonitrogen to support metabolism under different …
LPS-induced inflammation downregulates mammary gland glucose, fatty acid, and L-carnitine transporter expression at different lactation stages
Glucose, fatty acids, and l-carnitine are important substrates that support mammary epithelial
cell metabolism, biosynthetic capacity, and milk yield and composition. Our study …
cell metabolism, biosynthetic capacity, and milk yield and composition. Our study …
Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats
Y Lou, J Li, Y Lu, X Wang, R Jiao, S Wang, L Kong - Toxicology letters, 2011 - Elsevier
Aristolochic acid (AA) nephropathy exhibits early proximal tubular injury and fatty acid
metabolic disorder. In order to study the unrecognized abnormalities of organic ion …
metabolic disorder. In order to study the unrecognized abnormalities of organic ion …
Upregulation of mammary gland OCTNs maintains carnitine homeostasis in suckling infants
AM Lamhonwah, L Mai, C Chung… - Biochemical and …, 2011 - Elsevier
Background: Transport of l-carnitine, essential cofactor of fatty acid metabolism, into breast
milk is critical for the normal growth and development of the suckling infant. Objective: To …
milk is critical for the normal growth and development of the suckling infant. Objective: To …