Despite improvements in the understanding of cancer causation, much remains unknown
regarding the mechanisms by which genomic and non-genomic factors initiate …

Breast cancer is the commonest females' cancer and the leading cause of cancer death
worldwide. There is a substantial rise in the incidence of breast cancer in Saudi Arabia in …

Genetic diversity of germline variants in breast cancer (BC) predisposition genes is
unexplored in miscegenated populations, such those living in Latin America. We evaluated …

The current study aimed to identify new breast and/or ovarian cancer predisposition genes.
For that, whole‐exome sequencing (WES) was performed in the germline DNA of 52 non …

The detection of germline mutations in BRCA1 and BRCA 2 is essential to the formulation of
clinical management strategies, and in Brazil, there is limited access to these services …

Abstract Background The Hereditary Breast and Ovarian Cancer Syndrome (HBOC) occurs
in families with a history of breast/ovarian cancer, presenting an autosomal dominant …

Ultraviolet radiation (UV) is causally linked to cutaneous melanoma, yet the underlying
epigenetic mechanisms, known as molecular sensors of exposure, have not been …

PURPOSE To report on pathogenic germline variants detected among individuals
undergoing genetic testing for hereditary breast and/or ovarian cancer (HBOC) from Latin …

Background Germline pathogenic variants in BRCA1 and BRCA2 (BRCA) are the main
cause of Hereditary Breast and Ovarian Cancer syndrome (HBOC). Methods In this study we …

Background There is an increasing amount of data from Latin America on the
characterization of BRCA variants; however, there is limited information from Peru. We …