Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …
Prevalence and disease burden of chronic kidney disease
JC Lv, LX Zhang - Renal fibrosis: mechanisms and therapies, 2019 - Springer
Chronic kidney disease (CKD) has been recognized as a leading public health problem
worldwide. The global estimated prevalence of CKD is 13.4%(11.7–15.1%), and patients …
worldwide. The global estimated prevalence of CKD is 13.4%(11.7–15.1%), and patients …
Extracellular vesicles in cancer—implications for future improvements in cancer care
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …
cell–cell communication within complex tissue environments. Such communication …
Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …
NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo
G Jia, Y Han, Y An, Y Ding, C He, X Wang, Q Tang - Biomaterials, 2018 - Elsevier
Currently, glioma treatment is limited by two main factors: timely detection at onset or relapse
and restriction of drugs by the blood–brain barrier (BBB) from entering the brain and …
and restriction of drugs by the blood–brain barrier (BBB) from entering the brain and …
Tumour acidosis: from the passenger to the driver's seat
The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …
A biomimetic drug delivery system by integrating grapefruit extracellular vesicles and doxorubicin-loaded heparin-based nanoparticles for glioma therapy
W Niu, Q Xiao, X Wang, J Zhu, J Li, X Liang, Y Peng… - Nano …, 2021 - ACS Publications
Existing nanoparticle-mediated drug delivery systems for glioma systemic chemotherapy
remain a great challenge due to poor delivery efficiency resulting from the blood brain …
remain a great challenge due to poor delivery efficiency resulting from the blood brain …
Recent progresses in exosome-based systems for targeted drug delivery to the brain
S Bashyal, C Thapa, S Lee - Journal of Controlled Release, 2022 - Elsevier
Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …
[HTML][HTML] Designer exosomes: a new platform for biotechnology therapeutics
Desirable features of exosomes have made them a suitable manipulative platform for
biomedical applications, including targeted drug delivery, gene therapy, cancer diagnosis …
biomedical applications, including targeted drug delivery, gene therapy, cancer diagnosis …
[HTML][HTML] Extracellular vesicles in the tumor microenvironment: old stories, but new tales
L Han, EWF Lam, Y Sun - Molecular cancer, 2019 - Springer
Mammalian cells synthesize and release heterogeneous extracellular vesicles (EVs) which
can be generally recognized as subclasses including exosomes, microvesicles (MVs), and …
can be generally recognized as subclasses including exosomes, microvesicles (MVs), and …