The war against heart failure: the Lancet lecture

E Braunwald - The Lancet, 2015 - thelancet.com
Heart failure is a global problem with an estimated prevalence of 38 million patients
worldwide, a number that is increasing with the ageing of the population. It is the most …

From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

JJH Chong, X Yang, CW Don, E Minami, YW Liu… - Nature, 2014 - nature.com
Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure by
providing human cardiomyocytes to support heart regeneration. Studies of human …

Modulating the stem cell niche for tissue regeneration

SW Lane, DA Williams, FM Watt - Nature biotechnology, 2014 - nature.com
The field of regenerative medicine holds considerable promise for treating diseases that are
currently intractable. Although many researchers are adopting the strategy of cell …

Restoring function after spinal cord injury: towards clinical translation of experimental strategies

LM Ramer, MS Ramer, EJ Bradbury - The Lancet Neurology, 2014 - thelancet.com
Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

Ethical issues in stem cell research and therapy

NMP King, J Perrin - Stem Cell Research & Therapy, 2014 - Springer
Rapid progress in biotechnology has introduced a host of pressing ethical and policy issues
pertaining to stem cell research. In this review, we provide an overview of the most …

[HTML][HTML] Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: achievements and future direction

AKL Chen, S Reuveny, SKW Oh - Biotechnology advances, 2013 - Elsevier
Mesenchymal stem cells (MSCs) have recently made significant progress with multiple
clinical trials targeting modulation of immune responses, regeneration of bone, cartilage …

[HTML][HTML] Stem and progenitor cell-based therapy of the central nervous system: hopes, hype, and wishful thinking

SA Goldman - Cell stem cell, 2016 - cell.com
A variety of neurological disorders are attractive targets for stem and progenitor cell-based
therapy. Yet many conditions are not, whether by virtue of an inhospitable disease …

The role of biomaterials in peripheral nerve and spinal cord injury: a review

B Kaplan, S Levenberg - International journal of molecular sciences, 2022 - mdpi.com
Peripheral nerve and spinal cord injuries are potentially devastating traumatic conditions
with major consequences for patients' lives. Severe cases of these conditions are currently …

Print me an organ? Ethical and regulatory issues emerging from 3D bioprinting in medicine

F Gilbert, CD O'Connell, T Mladenovska… - Science and engineering …, 2018 - Springer
Recent developments of three-dimensional printing of biomaterials (3D bioprinting) in
medicine have been portrayed as demonstrating the potential to transform some medical …