Type 2 diabetes mellitus in older adults: clinical considerations and management

S Bellary, I Kyrou, JE Brown, CJ Bailey - Nature Reviews Endocrinology, 2021 - nature.com
The past 50 years have seen a growing ageing population with an increasing prevalence of
type 2 diabetes mellitus (T2DM); now, nearly half of all individuals with diabetes mellitus are …

Emerging targets in type 2 diabetes and diabetic complications

S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

[HTML][HTML] A narrative review on sarcopenia in type 2 diabetes mellitus: prevalence and associated factors

A Izzo, E Massimino, G Riccardi, G Della Pepa - Nutrients, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) represents a major health burden for the elderly
population, affecting approximately 25% of people over the age of 65 years. This percentage …

[HTML][HTML] Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines

J Bilski, P Pierzchalski, M Szczepanik, J Bonior… - Cells, 2022 - mdpi.com
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

[HTML][HTML] Prevalence of sarcopenia and its impact on cardiovascular events and mortality among dialysis patients: a systematic review and meta-analysis

W Wathanavasin, A Banjongjit, Y Avihingsanon… - Nutrients, 2022 - mdpi.com
Sarcopenia in end-stage kidney disease patients requiring dialysis is a frequent
complication but remains an under-recognized problem. This meta-analysis was conducted …

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

Sarcopenia definition: does it really matter? Implications for resistance training

C Smith, MN Woessner, M Sim, I Levinger - Ageing research reviews, 2022 - Elsevier
The loss of muscle mass, strength and function, known as sarcopenia, is common in older
adults, and is associated with falls, fractures, cardiometabolic diseases, and lower quality of …

[HTML][HTML] Diabetic muscular atrophy: molecular mechanisms and promising therapies

Y Shen, M Li, K Wang, G Qi, H Liu, W Wang… - Frontiers in …, 2022 - frontiersin.org
Diabetes mellitus (DM) is a typical chronic disease that can be divided into 2 types,
dependent on insulin deficiency or insulin resistance. Incidences of diabetic complications …

The association between sarcopenia and diabetes: from pathophysiology mechanism to therapeutic strategy

H Chen, X Huang, M Dong, S Wen… - … Syndrome and Obesity, 2023 - Taylor & Francis
Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-
related disorder characterized by loss of skeletal muscle mass and function, is recognized …

[HTML][HTML] Diabetes and bone fragility

C Romero-Díaz, D Duarte-Montero… - Diabetes Therapy, 2021 - Springer
Diabetes is a highly prevalent disease with complications that impact most bodily systems.
However, the impact of diabetes on bone health is frequently ignored or underestimated …