Vertebrate ancestors had only cone-like photoreceptors. The duplex retina evolved in
jawless vertebrates with the advent of highly photosensitive rod-like photoreceptors. Despite …

Quantitative trait loci (QTLs) are being used to study genetic networks, protein functions, and
systems properties that underlie phenotypic variation and disease risk in humans, model …

We purpose here to analyze and compare the population and topography of cone
photoreceptors in two mouse strains using automated routines, and to design a method of …

We illustrate the growing power of the BXD family of mice (recombinant inbred strains from a
cross of C57BL/6J and DBA/2J mice) and companion bioinformatic tools to study complex …

Purpose.: We evaluated the relationship between cone photoreceptor packing density and
outer nuclear layer (ONL) thickness within the central 15 degrees. Methods.: Individual …

The retina contains two populations of cholinergic amacrine cells, one positioned in the
ganglion cell layer (GCL) and the other in the inner nuclear layer (INL), that together …

The sizes of different neuronal populations within the CNS are precisely controlled, but
whether neuronal number is coordinated between cell types is unknown. We examined the …

The tumor suppressor p53 is a major regulator of genes important for cell cycle arrest,
senescence, apoptosis, and innate immunity, and has recently been implicated in retinal …

The establishment of neuronal circuitry during development relies upon the action of cell-
intrinsic mechanisms that specify neuronal form as well as plastic processes that require the …

Disruption of cellular processes affected by multiple genes and accumulation of numerous
insults throughout life dictate the progression of age-related disorders, but their complex …