Sex differences in Alzheimer disease—the gateway to precision medicine

MT Ferretti, MF Iulita, E Cavedo, PA Chiesa… - Nature Reviews …, 2018 - nature.com
Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural
syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic …

Understanding the impact of sex and gender in Alzheimer's disease: a call to action

RA Nebel, NT Aggarwal, LL Barnes, A Gallagher… - Alzheimer's & …, 2018 - Elsevier
Introduction Precision medicine methodologies and approaches have advanced our
understanding of the clinical presentation, development, progression, and management of …

Sex differences in cognitive decline among US adults

DA Levine, AL Gross, EM Briceño, N Tilton… - JAMA network …, 2021 - jamanetwork.com
Importance Sex differences in dementia risk are unclear, but some studies have found
greater risk for women. Objective To determine associations between sex and cognitive …

Sex/gender differences in verbal fluency and verbal-episodic memory: a meta-analysis

M Hirnstein, J Stuebs, A Moè… - Perspectives on …, 2023 - journals.sagepub.com
Women are thought to fare better in verbal abilities, especially in verbal-fluency and verbal-
memory tasks. However, the last meta-analysis on sex/gender differences in verbal fluency …

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

DP Veitch, MW Weiner, PS Aisen, LA Beckett… - Alzheimer's & …, 2019 - Elsevier
Introduction The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …

Endogenous and exogenous estrogen exposures: how women's reproductive health can drive brain aging and inform Alzheimer's prevention

S Jett, N Malviya, E Schelbaum, G Jang… - Frontiers in Aging …, 2022 - frontiersin.org
After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …

Considering biological sex in traumatic brain injury

A Biegon - Frontiers in neurology, 2021 - frontiersin.org
Published epidemiological studies of traumatic brain injury (TBI) of all severities consistently
report higher incidence in men. Recent increases in the participation of women in sports and …

Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective

MM Mielke, NT Aggarwal, C Vila‐Castelar… - Alzheimer's & …, 2022 - Wiley Online Library
Sex or gender differences in the risk of Alzheimer's disease and related dementias (ADRD)
differ by world region, suggesting that there are potentially modifiable risk factors for …

Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression

AA Tsiknia, SD Edland, EE Sundermann, ET Reas… - Molecular …, 2022 - nature.com
Studies have shown that women on the Alzheimer's disease (AD) continuum have more
pathological tau in the brain and cerebrospinal fluid (CSF), than men. Some studies have …

How to characterize the function of a brain region

S Genon, A Reid, R Langner, K Amunts… - Trends in cognitive …, 2018 - cell.com
Many brain regions have been defined, but a comprehensive formalization of each region's
function in relation to human behavior is still lacking. Current knowledge comes from various …