Overcoming Treatment Resistance in Medulloblastoma: Underlying Mechanisms and Potential Strategies
H Slika, A Shahani, R Wahi, J Miller, M Groves, B Tyler - Cancers, 2024 - mdpi.com
Simple Summary Medulloblastoma is the most common type of malignant brain tumor that
occurs in the pediatric population. It is associated with significant morbidity and mortality due …
occurs in the pediatric population. It is associated with significant morbidity and mortality due …
Measurement and Modeling of Transport Across the Blood–Brain Barrier
The blood–brain barrier (BBB) is a dynamic regulatory barrier at the interface of blood
circulation and the brain parenchyma, which plays a critical role in protecting homeostasis in …
circulation and the brain parenchyma, which plays a critical role in protecting homeostasis in …
Breaking down the barrier to medulloblastoma treatment: Piezo2 knockout disrupts the BTB and increases vascular permeability
SA Sprowls, JD Lathia - Neuron, 2023 - cell.com
In this issue, Chen et al. 1 show that genetic knockout of Piezo2 in SOX2+ medulloblastoma
cells decreased local tissue stiffness, increased drug delivery across the blood-tumor …
cells decreased local tissue stiffness, increased drug delivery across the blood-tumor …