The leucine-rich repeat as a protein recognition motif
Leucine-rich repeats (LRRs) are 20–29-residue sequence motifs present in a number of
proteins with diverse functions. The primary function of these motifs appears to be to provide …
proteins with diverse functions. The primary function of these motifs appears to be to provide …
NODs: intracellular proteins involved in inflammation and apoptosis
N Inohara, G Nunez - Nature Reviews Immunology, 2003 - nature.com
NOD (nucleotide-binding oligomerization domain) proteins are members of a family that
includes the apoptosis regulator APAF1 (apoptotic protease activating factor 1), mammalian …
includes the apoptosis regulator APAF1 (apoptotic protease activating factor 1), mammalian …
NALPs: a novel protein family involved in inflammation
J Tschopp, F Martinon, K Burns - Nature reviews Molecular cell biology, 2003 - nature.com
A newly discovered family of cytoplasmic proteins—the NALPs—has been implicated in the
activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to …
activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to …
Genetic control of MHC class II expression
JPY Ting, J Trowsdale - Cell, 2002 - cell.com
The presentation of peptides to T cells by MHC class II molecules is of critical importance in
specific recognition by the immune system. Expression of class II molecules is exquisitely …
specific recognition by the immune system. Expression of class II molecules is exquisitely …
STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns …
Using sequence profile analysis and sequence-based structure predictions, we define a
previously unrecognized, widespread class of P-loop NTPases. The signal transduction …
previously unrecognized, widespread class of P-loop NTPases. The signal transduction …
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders
M Fukata, AS Vamadevan, MT Abreu - Seminars in immunology, 2009 - Elsevier
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are two major forms of innate
immune sensors, which provide immediate responses against pathogenic invasion or tissue …
immune sensors, which provide immediate responses against pathogenic invasion or tissue …
CATERPILLER: a novel gene family important in immunity, cell death, and diseases
JPY Ting, BK Davis - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract The newly discovered CATERPILLER (CLR) gene family encodes proteins with a
variable but limited number of N-terminal domains, followed by a nucleotide-binding domain …
variable but limited number of N-terminal domains, followed by a nucleotide-binding domain …
Nods, Nalps and Naip: intracellular regulators of bacterial‐induced inflammation
M Chamaillard, SE Girardin, J Viala… - Cellular …, 2003 - Wiley Online Library
The innate immune system is the most ancestral and ubiquitous system of defence against
microbial infection. The microbial sensing proteins involved in innate immunity recognize …
microbial infection. The microbial sensing proteins involved in innate immunity recognize …
CATERPILLERs, pyrin and hereditary immunological disorders
JPY Ting, DL Kastner, HM Hoffman - Nature Reviews Immunology, 2006 - nature.com
The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is
comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This …
comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This …
The role of Toll-like receptors and Nod proteins in bacterial infection
DJ Philpott, SE Girardin - Molecular immunology, 2004 - Elsevier
Our understanding of innate immunity in mammals has greatly expanded following the
discovery of the family of membrane-bound receptors, called the Toll-like receptors (TLRs) …
discovery of the family of membrane-bound receptors, called the Toll-like receptors (TLRs) …